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Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis

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dc.creatorOrtega-Hernandez, Oscar-Danilospa
dc.creatorPineda-Tamayo, Ricardospa
dc.creatorPardo, Aryce L.spa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:04:33Z
dc.date.available2020-05-26T00:04:33Z
dc.date.created2009spa
dc.description.abstractThe objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and clinical characteristics including disease activity, inflammatory markers, co-morbidities, cardiovascular (CV) risk factors, history of familial autoimmunity and therapy was recorded. The presence of HLA 'shared epitope' (SE) alleles and TNF gene polymorphism was assessed. A multivariate statistical analysis was performed. ExRA was found in 32% of the patients, of which nodulosis, Sjögren's syndrome, and lung involvement were registered in 21%, 9%, and 4% of patients, respectively. Patients with ExRA were older than patients without it and they presented longer disease duration as well. Thus, an association between disease duration and ExRA manifestations was also observed. Patients with ExRA presented significant higher titers of anti-CCP antibodies as compared to patients without ExRA. Hypertension and thrombosis were significantly associated with ExRA. Never having smoked constituted a protective factor against ExRA onset. Associations between ExRA and the presence of traditional CV risk factors were also found. Our results show that duration of RA, CV disease and high titers of anti-CCP antibodies are associated with ExRA in Colombian patients with RA, and highlight the importance of preventing smoking in those who are prone to develop autoimmune diseases including RA. © Clinical Rheumatology 2009.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s10067-009-1145-8
dc.identifier.issn7703198
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23694
dc.language.isoengspa
dc.relation.citationEndPage775
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage767
dc.relation.citationTitleClinical Rheumatology
dc.relation.citationVolumeVol. 28
dc.relation.ispartofClinical Rheumatology, ISSN:7703198, Vol.28, No.7 (2009); pp. 767-775spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-67349175002&doi=10.1007%2fs10067-009-1145-8&partnerID=40&md5=bc155402acc7aec78242175967db994bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCyclic citrullinated peptide antibodyspa
dc.subject.keywordDisease modifying antirheumatic drugspa
dc.subject.keywordsouth americaneng
dc.subject.keywordrheumatoideng
dc.subject.keywordcycliceng
dc.subject.keywordHla antigenspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordSteroidspa
dc.subject.keywordTumor necrosis factorspa
dc.subject.keywordAdultspa
dc.subject.keywordAgespa
dc.subject.keywordAnemiaspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordArticlespa
dc.subject.keywordCardiovascular diseasespa
dc.subject.keywordCardiovascular riskspa
dc.subject.keywordCigarette smokingspa
dc.subject.keywordClinical featurespa
dc.subject.keywordColombiaspa
dc.subject.keywordComorbidityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDemographyspa
dc.subject.keywordDisease activityspa
dc.subject.keywordDisease associationspa
dc.subject.keywordDisease durationspa
dc.subject.keywordDna polymorphismspa
dc.subject.keywordExtra articular rheumatoid arthritisspa
dc.subject.keywordFamily historyspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHumanspa
dc.subject.keywordHypertensionspa
dc.subject.keywordLung diseasespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRheumatoid nodulespa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordThrombosisspa
dc.subject.keywordArthritiseng
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordCardiovascular diseasesspa
dc.subject.keywordColombiaspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordEuropean continental ancestry groupspa
dc.subject.keywordFemalespa
dc.subject.keywordGenotypespa
dc.subject.keywordHistocompatibility testingspa
dc.subject.keywordHla-dq antigensspa
dc.subject.keywordHla-dr antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordIndianseng
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPeptideseng
dc.subject.keywordRisk factorsspa
dc.subject.keywordTime factorsspa
dc.subject.keywordCardiovascular diseasespa
dc.subject.keywordExtra-articular manifestationsspa
dc.subject.keywordHlaspa
dc.subject.keywordLatin americaspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSmokingspa
dc.titleCardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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