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Lack of association of polymorphisms in six candidate genes in Colombian adhd patients

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dc.creatorFonseca Mendoza, Dora Janeth
dc.creatorMateus, Heidi Espa
dc.creatorGálvez, Jubby Mspa
dc.creatorForero, Diego Aspa
dc.creatorTalero Gutiérrez, Claudia
dc.creatorVélez van Meerbeke, Alberto Franciscospa
dc.date.accessioned2020-05-25T23:56:00Z
dc.date.available2020-05-25T23:56:00Z
dc.date.created2015spa
dc.description.abstractBackground: Attention Deficit and Hyperactivity Disorder (ADHD) is a common childhood neuropsychiatric condition. The disorder has a multifactorial background, with heritability estimates of around 76%, suggesting an important role of genetic factors. Candidate genes include those related to dopaminergic (e.g. DRD4, DRD5, SLC6A3 and DBH)and serotoninergic (e.g.HTR1B and SLC6A4) pathways. Purpose: To explore the association of common polymorphisms in six genes (DRD4, DRD5, SLC6A3, DBH, HTR1B and SLC6A4) and the susceptibility to ADHD in a Colombian sample population. Methods: Eighty-six ADHD trios and 152 healthy controls were recruited. Genotyping of the six polymorphisms was performed using described PCR-based protocols. A TDT analysis was used to test if there was preferential allelic transmission for any of the six polymorphisms. Additionally, a case-control analysis was performed to test for association of the serotoninergic (HTR1B and SLC6A4) polymorphisms with ADHD. Results: Through the TDT analysis there was no preferential allelic transmission for any of the studied variants. Case-control analysis did not show association. Conclusion: This is the first study in Latin America to describe six polymorphisms in a group of patients with ADHD. There was no evidence of association for any of the studied polymorphic variants in this Colombian ADHD sample. Further research, with larger sample sizes and study of endophenotypes, is needed in this population to confirm and extend the results. © 2015, Indian Academy of Neurosciences. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.5214/ans.0972.7531.220405
dc.identifier.issn09763260
dc.identifier.issn09727531
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22289
dc.language.isoengspa
dc.publisherIndian Academy of Neurosciencesspa
dc.relation.citationEndPage221
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage217
dc.relation.citationTitleAnnals of Neurosciences
dc.relation.citationVolumeVol. 22
dc.relation.ispartofAnnals of Neurosciences, ISSN:09763260, 09727531, Vol.22, No.4 (2015); pp. 217-221spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84928809847&doi=10.5214%2fans.0972.7531.220405&partnerID=40&md5=e3ad25370ae18db3392ae0fa737dcc20spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDopamine 4 receptorspa
dc.subject.keywordDopamine 5 receptorspa
dc.subject.keywordDopamine transporterspa
dc.subject.keywordSerotonin 1b receptorspa
dc.subject.keywordSerotonin transporterspa
dc.subject.keywordAdolescentspa
dc.subject.keywordArticlespa
dc.subject.keywordAttention deficit disorderspa
dc.subject.keywordCase control studyspa
dc.subject.keywordChildspa
dc.subject.keywordClinical protocolspa
dc.subject.keywordColombianspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDbh genespa
dc.subject.keywordDisease activityspa
dc.subject.keywordDrd4 genespa
dc.subject.keywordDrd5 genespa
dc.subject.keywordGenespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene functionspa
dc.subject.keywordGene identificationspa
dc.subject.keywordGene locationspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGenotyping techniquespa
dc.subject.keywordHtr1b genespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMolecular dynamicsspa
dc.subject.keywordMolecular pathologyspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPreschool childspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSlc6a3 genespa
dc.subject.keywordSlc6a4 genespa
dc.subject.keywordAssociationspa
dc.subject.keywordAttention deficit and hyperactivityspa
dc.subject.keywordDisorderspa
dc.subject.keywordGenesspa
dc.subject.keywordLatin americaspa
dc.subject.keywordTransmission disequilibrium testspa
dc.titleLack of association of polymorphisms in six candidate genes in Colombian adhd patientsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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