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Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion

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dc.creatorLópez, Ramsésspa
dc.creatorValbuena, Johnspa
dc.creatorRodríguez, Luis E.spa
dc.creatorOcampo, Marisol
dc.creatorVera, Ricardospa
dc.creatorCurtidor, Hernandospa
dc.creatorPuentes, Alvarospa
dc.creatorGarcía, Javierspa
dc.creatorRamirez, Luis E.spa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-08-19T14:40:09Z
dc.date.available2020-08-19T14:40:09Z
dc.date.created2006-07spa
dc.description.abstractThis work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in the amino terminal region and 31191 (361EIDSTINNLVQEMIHLFSNNY380) at the carboxy terminal. Their binding to erythrocytes was saturable. HABPs 31191 and 31178 recognized 56 and 26 kDa receptors on erythrocyte membrane and inhibited in vitro Plasmodium falciparum merozoite invasion of erythrocytes by between 27% and 46% at 200 ?g ml?1 concentration, suggesting that these MSP-6 protein peptides play a possible role in the invasion process.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.peptides.2006.02.001
dc.identifier.issnISSN: 0196-9781
dc.identifier.issnEISSN: 1873-5169
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26738
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage1692
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1685
dc.relation.citationTitlePeptides
dc.relation.citationVolumeVol. 27
dc.relation.ispartofPeptides, ISSN: 0196-9781;EISSN: 1873-5169, Vol.27, No.7 (2006); pp. 1685-1692 spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0196978106000763spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourcePeptidesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordInvasionspa
dc.subject.keywordReceptorspa
dc.subject.keywordLigandspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordVaccinespa
dc.subject.keywordMSP-6spa
dc.subject.keywordBindingspa
dc.titlePlasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasionspa
dc.title.TranslatedTitleLos péptidos derivados de la proteína de superficie 6 del merozoito de Plasmodium falciparum (MSP-6) se unen a los eritrocitos e inhiben parcialmente la invasión del parásitospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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