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Cost-Effectiveness Analysis of Diagnosis of Duchenne/Becker Muscular Dystrophy in Colombia

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dc.creatorAtehortúa, Sara C.spa
dc.creatorLugo, Luz H.spa
dc.creatorCeballos, Mateospa
dc.creatorOrozco, Estebanspa
dc.creatorCastro, Paula A.spa
dc.creatorArango, Juan C.spa
dc.creatorMateus, Heidi E.spa
dc.date.accessioned2020-05-26T00:02:18Z
dc.date.available2020-05-26T00:02:18Z
dc.date.created2018spa
dc.description.abstractObjectives: To determine the cost-effectiveness ratio of different courses of action for the diagnosis of Duchenne or Becker muscular dystrophy in Colombia. Methods: The cost-effectiveness analysis was performed from the Colombian health system perspective. Decision trees were constructed, and different courses of action were compared considering the following tests: immunohistochemistry (IHC), Western blot (WB), multiplex polymerase chain reaction, multiplex ligation-dependent probe amplification (MLPA), and the complete sequencing of the dystrophin gene. The time horizon matched the duration of sample extraction and analysis. Transition probabilities were obtained from a systematic review. Costs were constructed with a type-case methodology using the consensus of experts and the valuation of resources from consulting laboratories and the 2001 Social Security Institute cost manual. Deterministic sensitivity and scenario analyses were performed with one or more unavailable alternatives. Costs were converted from Colombian pesos to US dollars using the 2014 exchange rate. Results: In the base case, WB was the dominant strategy, with a cost of US $419.07 and a sensitivity of 100%. This approach remains the dominant strategy down to a 98.2% sensitivity and while costs do not exceed US $837.38. If WB was not available, IHC had the best cost-effectiveness ratio, followed by MLPA and sequencing. Conclusions: WB is a cost-effective alternative for the diagnosis of patients suspected of having Duchenne or Becker muscular dystrophy in the Colombian health system. The IHC test is rated as the second-best detection method. If these tests are not available, MLPA followed by sequencing would be the most cost-effective alternative. © 2018eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vhri.2017.10.003
dc.identifier.issn22121099
dc.identifier.issn22121102
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23469
dc.language.isoengspa
dc.publisherElsevier Inc.spa
dc.relation.citationEndPage6
dc.relation.citationStartPage1
dc.relation.citationTitleValue in Health Regional Issues
dc.relation.citationVolumeVol. 17
dc.relation.ispartofValue in Health Regional Issues, ISSN:22121099, 22121102, Vol.17,(2018); pp. 1-6spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85043400151&doi=10.1016%2fj.vhri.2017.10.003&partnerID=40&md5=801e0345a7dea85abc3aee5e1508dbf8spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCreatine kinasespa
dc.subject.keywordwesterneng
dc.subject.keywordDystrophinspa
dc.subject.keywordArticlespa
dc.subject.keywordBecker muscular dystrophyspa
dc.subject.keywordColombiaspa
dc.subject.keywordCost effectiveness analysisspa
dc.subject.keywordDecision treespa
dc.subject.keywordDiagnostic procedurespa
dc.subject.keywordDiagnostic test accuracy studyspa
dc.subject.keywordDuchenne muscular dystrophyspa
dc.subject.keywordDystrophin genespa
dc.subject.keywordElectromyographyspa
dc.subject.keywordFalse negative resultspa
dc.subject.keywordGenespa
dc.subject.keywordHealth care costspa
dc.subject.keywordHealth care systemspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunohistochemistryspa
dc.subject.keywordLaboratory testspa
dc.subject.keywordMedical expertspa
dc.subject.keywordMultiplex ligation dependent probe amplificationspa
dc.subject.keywordMultiplex polymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProbabilityspa
dc.subject.keywordSensitivity and specificityspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordWestern blottingspa
dc.subject.keywordColombiaspa
dc.subject.keywordCost benefit analysisspa
dc.subject.keywordDuchenne muscular dystrophyspa
dc.subject.keywordEconomicsspa
dc.subject.keywordGenetic proceduresspa
dc.subject.keywordGeneticsspa
dc.subject.keywordLaboratory techniquespa
dc.subject.keywordProceduresspa
dc.subject.keywordBlottingeng
dc.subject.keywordClinical laboratory techniquesspa
dc.subject.keywordColombiaspa
dc.subject.keywordCost-benefit analysisspa
dc.subject.keywordDystrophinspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunohistochemistryspa
dc.subject.keywordMolecular probe techniquesspa
dc.subject.keywordMuscular dystrophyeng
dc.subject.keywordBeckerspa
dc.subject.keywordCost-effectiveness analysisspa
dc.subject.keywordDuchennespa
dc.subject.keywordEconomic evaluationspa
dc.subject.keywordImmunohistochemistryspa
dc.subject.keywordMlpaspa
dc.subject.keywordMuscular dystrophyspa
dc.subject.keywordPcrspa
dc.subject.keywordSequencingspa
dc.subject.keywordWestern blotspa
dc.titleCost-Effectiveness Analysis of Diagnosis of Duchenne/Becker Muscular Dystrophy in Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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