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Studies of plasmodium falciparum rhoptry-associated membrane antigen (RAMA) protein peptides specifically binding to human RBC

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dc.creatorPinzón, Carlos Giovannispa
dc.creatorCurtidor, Hernandospa
dc.creatorBermudez, Adriana
dc.creatorForero, Marthaspa
dc.creatorVanegas, Magnoliaspa
dc.creatorRodríguez, Jorgespa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-08-19T14:40:43Z
dc.date.available2020-08-19T14:40:43Z
dc.date.created2008-02-06spa
dc.description.abstractPlasmodium falciparum rhoptry-associated membrane antigen (RAMA) peptides used in normal red blood cell (RBC) binding assays revealed that peptides 33426 (79NINILSSVHRKGRILYDSF97) and 33460 (777HKKREKSISPHSYQKVSTKVQ797) bound with high activity, presenting nanomolar affinity constants. Such high binding activity peptides (HABPs) displayed helicoid and random coil structures as determined by circular dichroism. HABPs inhibited P. falciparum in vitro invasion of normal RBC by up to 61% (depending on concentration), suggesting that some RAMA protein regions could be involved in P. falciparum invasion of RBC. The nature and localisation of receptors on RBC surface responsible for HABP binding were studied using enzyme-treated erythrocytes and structural analysis.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2007.11.086
dc.identifier.issnISSN: 0264-410X
dc.identifier.issnEISSN: 1873-2518
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27002
dc.language.isoengspa
dc.publisherThe Japanese Society for Vaccinologyspa
dc.publisherElsevierspa
dc.relation.citationEndPage862
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage853
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 26
dc.relation.ispartofVaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.26, No.6 (2008); pp. 853-862 spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0264410X07013072?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceVaccinespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordP. falciparumspa
dc.subject.keywordRAMAspa
dc.subject.keywordRhoptryspa
dc.subject.keywordHABPspa
dc.titleStudies of plasmodium falciparum rhoptry-associated membrane antigen (RAMA) protein peptides specifically binding to human RBCspa
dc.title.TranslatedTitleEstudios de péptidos de la proteína del antígeno de membrana asociado a rhoptry (RAMA) de Plasmodium falciparum que se unen específicamente a los glóbulos rojos humanosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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