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The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac disease

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dc.creatorCherñavsky, Alejandra Claudiaspa
dc.creatorPáez, María Carolinaspa
dc.creatorPeriolo, Nataliaspa
dc.creatorCorrea, Paulaspa
dc.creatorGuillén, Lauraspa
dc.creatorNiveloni, Sonia Isabelspa
dc.creatorMauriño, Eduardospa
dc.creatorBai, Julio Césarspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:05:50Z
dc.date.available2020-05-26T00:05:50Z
dc.date.created2008spa
dc.description.abstractTo assess the joint contribution of interleukin 1 beta (IL-1B) and tumor necrosis factor alpha (TNF?) to the genetic risk of developing celiac disease (CD), we analyzed four biallelic polymorphisms of TNFA and IL-1B genes in 228 patients and 244 healthy controls. The individual contribution of TNFA -308A and IL-1B -511C alleles was weak (OR 1.47 and 1.66, respectively) and was null for TNFA -238 A/G and IL-1B +3953 C/T single nucleotide polymorphisms (SNPs). Due to the potential linkage disequilibrium between TNFA, human leukocyte antigen (HLA) -DQA1 and HLA-DQB1 genes, only individuals carrying DQ2 antigen (DQ2-positive) were considered to perform haplotype analyses. Two-position risk haplotypes were first defined by the combined presence of -511C and +3953T alleles for IL-1B (OR 9.402) or -308A and -238A alleles for TNFA (OR 15.389). The TNFA/IL-1B combined haplotype-stratified association analysis showed that the simultaneous presence of TNFA risk and IL-1B non-risk haplotypes (OR 13.32) but not TNFA non-risk and IL-1B risk haplotypes (OR 0.71) is associated with CD. Interestingly, our data suggest that the coexistence of both risk haplotypes seems to work synergistically (OR 29.59), which enhances the risk of developing CD. © 2008 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.cyto.2008.01.015
dc.identifier.issn10960023
dc.identifier.issn10434666
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23831
dc.language.isoengspa
dc.relation.citationEndPage54
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage48
dc.relation.citationTitleCytokine
dc.relation.citationVolumeVol. 42
dc.relation.ispartofCytokine, ISSN:10960023, 10434666, Vol.42, No.1 (2008); pp. 48-54spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-41149096930&doi=10.1016%2fj.cyto.2008.01.015&partnerID=40&md5=695454d33140e6bf55e1f6ded53b6531spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHLA DQA1 antigenspa
dc.subject.keywordDNAeng
dc.subject.keywordGeneticeng
dc.subject.keywordHLA DQB1 antigenspa
dc.subject.keywordInterleukin 1betaspa
dc.subject.keywordTumor necrosis factor alphaspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordCeliac diseasespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease coursespa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene linkage disequilibriumspa
dc.subject.keywordGene locationspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordHaplotypespa
dc.subject.keywordHeterozygotespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPriority journalspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAllelesspa
dc.subject.keywordCeliac Diseasespa
dc.subject.keywordFemalespa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHLA-DQ Antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordInterleukin-1betaspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSequence Analysiseng
dc.subject.keywordTumor Necrosis Factor-alphaspa
dc.subject.keywordCeliac diseasespa
dc.subject.keywordIL-1Bspa
dc.subject.keywordPolymorphismsspa
dc.subject.keywordTNFAspa
dc.titleThe simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac diseasespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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