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Pharmacological treatment and impairment of pulmonary function in patients with type 2 diabetes: A cross-sectional study

dc.creatorVargas, Henry A.spa
dc.creatorRondón, Martínspa
dc.creatorDennis Verano, Rodolfo José
dc.date.accessioned2020-05-26T00:02:56Z
dc.date.available2020-05-26T00:02:56Z
dc.date.created2016spa
dc.description.abstractIntroduction: There is no clear relationship between type 2 diabetes mellitus and lung function decline; it is also unclear whether the type of treatment can modify spirometric variables and levels of inflammatory biomarkers. Objectives: To compare pulmonary function in patients with type 2 diabetes treated with an insulin-sensitizing agent (metformin) and in those treated with secretagogues, as well as combined with insulin, and to evaluate differences in inflammatory biomarkers between treatment groups. Material and methods: We conducted a cross-sectional analytic study in 196 diabetic patients with type 2 diabetic mellitus. Spirometric variables and levels of inflammatory biomarkers (ferritin, fibrinogen, C-reactive protein, interleukin 6, tumor necrosis factor-alpha), were obtained. Residual values (observed minus expected) for forced vital capacity and for forced expiratory volume were calculated and compared between treatment types. Differences in median levels of biomarkers were also compared. Results: After adjustment by known determinants of lung function, and by the control and duration of type 2 diabetes, patients treated with the insulin-sensitizing agent had statistically significant lower differences against expected values for forced vital capacity compared with secretagogues (-212.1 ml vs 270.2 ml, p=0.039), as well as for forced expiratory volume, but without statistical significance (-133.2 mL vs -174.8 mL, p>0.05). In the group of patients treated with the insulin-sensitizing agent, ferritin and tumor necrosis factor-alpha levels were lower (p less than 0.01). Conclusion: This study supports the hypothesis that insulin-sensitizing agents appear to be associated with less deterioration of lung function and less systemic inflammation in type 2 diabetes. The present study serves to formulate new hypothesis and research projects.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.7705/biomedica.v36i3.2752
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23542
dc.language.isoengspa
dc.publisherInstituto Nacional de Saludspa
dc.relation.citationEndPage284
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage276
dc.relation.citationTitleBiomedica
dc.relation.citationVolumeVol. 36
dc.relation.ispartofBiomedica, Vol.36, No.2 (2016); pp. 276-284spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84980316423&doi=10.7705%2fbiomedica.v36i3.2752&partnerID=40&md5=b4ded2c237c898540af38a73793844f8spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordC reactive proteinspa
dc.subject.keywordhumaneng
dc.subject.keywordInsulinspa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordTumor necrosis factorspa
dc.subject.keywordChemistryspa
dc.subject.keywordComplicationspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordForced expiratory volumespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunologyspa
dc.subject.keywordLungspa
dc.subject.keywordMetabolismspa
dc.subject.keywordNon insulin dependent diabetes mellitusspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordProceduresspa
dc.subject.keywordSpirometryspa
dc.subject.keywordC-Reactive Proteinspa
dc.subject.keywordCross-Sectional Studiesspa
dc.subject.keywordDiabetes Mellituseng
dc.subject.keywordForced Expiratory Volumespa
dc.subject.keywordHumansspa
dc.subject.keywordInsulinspa
dc.subject.keywordInterleukin-6spa
dc.subject.keywordLungspa
dc.subject.keywordSpirometryspa
dc.subject.keywordTumor Necrosis Factor-alphaspa
dc.subject.keywordDiabetes mellitusspa
dc.subject.keywordInflammationspa
dc.subject.keywordInsulinsspa
dc.subject.keywordLungspa
dc.subject.keywordMetforminspa
dc.titlePharmacological treatment and impairment of pulmonary function in patients with type 2 diabetes: A cross-sectional studyspa
dc.title.TranslatedTitleTratamiento farmacológico y deterioro de la función pulmonar en pacientes con diabetes de tipo 2: Un estudio de corte transversalspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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