Ítem
Solo Metadatos

The risk of defects in the neural tube caused by valproic acid and carbamazepine

Mostrar el registro sencillo de la publicación
dc.creatorGutiérrez-Álvarez A.M.spa
dc.creatorMoreno-López C.L.spa
dc.date.accessioned2020-05-25T23:59:54Z
dc.date.available2020-05-25T23:59:54Z
dc.date.created2005spa
dc.description.abstractObjective. To determine the risk, if any, of carbamazepine and valproic acid use on the foetus with respect to neural tube defects. Materials and methods. Databases such as MEDLINE, EMBASE, SCISEARCH, The Cochrane Library and LILACS were consulted to have access to published literature from January 1966 to September 2004. All articles published in English and Spanish were considered. A manual review of the references presented in each produced article was done in order to identify the articles that the electronic search may have not found itself. However, articles which seemed ambiguous as to the title and/or abstract were completely analyzed to establish their relevance. Studies that examined the effects of systematic exposure to carbamazepine or valproic acid during pregnancy and that assessed neural tube defects in the infants were eligible. The data was extracted in the form of 2 x 2 tables. The odds ratio (OR), relative risk (RR) and 95% confidence interval (CI) was calculated for each of the studies. Results. The pooled relative risk of neural tube defects among the exposed to valproic acid was 0.61 (95% CI: 0.06-6.72). The risk among the exposed to carbamazepine was 1.10 (95% CI: 0.16-7-75). Conclusions. Due to the methodologic limitations of most of the studies where the data was insufficient, only three studies could be included in the meta-analysis. There is not enough evidence to establish the risk raised in the objective of the study. © 2005, Revista de Neurología.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn2100010
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23129
dc.language.isoengspa
dc.relation.citationEndPage272
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage268
dc.relation.citationTitleRevista de Neurologia
dc.relation.citationVolumeVol. 41
dc.relation.ispartofRevista de Neurologia, ISSN:2100010, Vol.41, No.5 (2005); pp. 268-272spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-32944467050&partnerID=40&md5=75449e5df819d46fda1a629d2dcba699spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCarbamazepinespa
dc.subject.keywordValproic acidspa
dc.subject.keywordAnticonvulsive agentspa
dc.subject.keywordCarbamazepinespa
dc.subject.keywordValproic acidspa
dc.subject.keywordArticlespa
dc.subject.keywordClinical trialspa
dc.subject.keywordCochrane libraryspa
dc.subject.keywordEmbasespa
dc.subject.keywordEpilepsyspa
dc.subject.keywordHumanspa
dc.subject.keywordMedlinespa
dc.subject.keywordMeningomyelocelespa
dc.subject.keywordMeta analysisspa
dc.subject.keywordMonotherapyspa
dc.subject.keywordNeural tube defectspa
dc.subject.keywordPrenatal exposurespa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordTreatment durationspa
dc.subject.keywordChemically induced disorderspa
dc.subject.keywordCongenital malformationspa
dc.subject.keywordDrug effectspa
dc.subject.keywordFemalespa
dc.subject.keywordFetusspa
dc.subject.keywordNeural tube defectspa
dc.subject.keywordPregnancyspa
dc.subject.keywordPrenatal exposurespa
dc.subject.keywordRiskspa
dc.subject.keywordRisk factorspa
dc.subject.keywordAnticonvulsantsspa
dc.subject.keywordCarbamazepinespa
dc.subject.keywordFemalespa
dc.subject.keywordFetusspa
dc.subject.keywordHumansspa
dc.subject.keywordNeural tube defectsspa
dc.subject.keywordOdds ratiospa
dc.subject.keywordPregnancyspa
dc.subject.keywordPrenatal exposure delayed effectsspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordValproic acidspa
dc.subject.keywordCarbamazepinespa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordNeural tube defectsspa
dc.subject.keywordPrenatal exposure delayed effectsspa
dc.subject.keywordRelative riskspa
dc.subject.keywordValproic acidspa
dc.titleThe risk of defects in the neural tube caused by valproic acid and carbamazepinespa
dc.title.TranslatedTitleRiesgo de defectos del tubo neural con ácido valproico y carbamacepinaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos