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Aparición de fibrosis pulmonar en función del tiempo por exposición a nanotubos de carbón (CNT) : Revisión sistemática de la literatura a partir de estudios experimentales en animales en los últimos 15 años

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dc.contributorÁvila Bernal, Alba Graciela
dc.contributorBriceno-Ayala, Leonardo
dc.contributor.advisorOrduz García, Carlos Eduardo
dc.creatorPineda Blanco, Julian Orlando
dc.creatorGarcía Álvarez, Ana María
dc.creatorPáez Vásquez, Juan Manuel
dc.creator.degreeEspecialista en Salud Ocupacionalspa
dc.creator.degreetypeFull timespa
dc.date.accessioned2018-12-14T16:27:30Z
dc.date.available2018-12-14T16:27:30Z
dc.date.created2018-12-04
dc.date.embargoEndinfo:eu-repo/date/embargoEnd/2020-12-14
dc.date.issued2018
dc.descriptionIntroducción: El conocimiento de los nanotubos de carbón ha generado una amplia aplicación y exposición industrial. Esto facilita el desarrollo de fibrosis pulmonar por exposición siendo una patología progresiva, multifactorial y refractaria al tratamiento. Aunque la relación exposición y fibrosis se ha documentado, aún existen interrogantes sobre el momento de aparición de la fibrosis. Objetivo: Revisar el estado del arte y graficar la relación tiempo y aparición de fibrosis pulmonar posterior a la exposición a nanotubos de carbón (CNT). Método: Con límite de fechas entre enero de 2003 y mayo de 2018 se revisaron bases de datos seleccionadas, se eliminaron referencias duplicadas, se filtró por criterios de inclusión y exclusión, se evaluaron títulos y resúmenes por dos investigadores y finalmente se aplicaron criterios de calidad y riesgos de sesgos para extraer posteriormente los datos y analizarlos de forma descriptiva. Resultados: Se seleccionaron 49 artículos en inglés, todos experimentales en animales, se evaluaron exposiciones por aspiración, instilación e inhalación. En estos estudios se utilizaron diferentes dosis, en algunos casos se realizaron ajustes según peso del animal o dependiendo de la vía de exposición. Se reporta fibrosis pulmonar en la mayoría de resultados desde el día 1 hasta 728. Dentro de la búsqueda solo un estudio fue reportado en humanos. Conclusión: A partir de la evidencia disponible aún no se logra establecer el momento específico de aparición de la fibrosis pulmonar posterior a la exposición a nanotubos de carbón; realizamos algunas recomendaciones para futuros estudios a fin de facilitar la consolidación de evidencia que permita posteriormente evaluar dicho efecto en ambientes ocupacionales y determinar tiempos de seguimiento a los trabajadores.spa
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dc.identifier.doihttps://doi.org/10.48713/10336_18831
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18831
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Salud Ocupacionalspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectAnimales experimentaciónspa
dc.subjectNanotubos de pared múltiplespa
dc.subjectNanotubos de pared simplespa
dc.subjectNanotubos de carbónspa
dc.subjectFibrosis pulmonarspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordMulti walled nanotubespa
dc.subject.keywordSingle walled nanotubespa
dc.subject.keywordCarbon nanotubespa
dc.subject.keywordLung fibrosisspa
dc.subject.lembFibrosis pulmonarspa
dc.subject.lembNanotubosspa
dc.titleAparición de fibrosis pulmonar en función del tiempo por exposición a nanotubos de carbón (CNT) : Revisión sistemática de la literatura a partir de estudios experimentales en animales en los últimos 15 añosspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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