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Bacterial translocation in abdominal trauma and postoperative infections

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dc.creatorNieves E.spa
dc.creatorTobón L.F.spa
dc.creatorRíos D.I.spa
dc.creatorIsaza Restrepo, Andrésspa
dc.creatorRamírez M.spa
dc.creatorBeltrán J.A.spa
dc.creatorGarzón-Ospina D.spa
dc.creatorPatarroyo M.A.spa
dc.creatorGómez A.spa
dc.date.accessioned2020-05-25T23:56:41Z
dc.date.available2020-05-25T23:56:41Z
dc.date.created2011spa
dc.description.abstractBackground: Bacterial translocation (BT) describes the passage of bacteria residing into the gastrointestinal tract, through the intestinal mucosa barrier to sterile tissues such as mesenteric lymph nodes (MLN) and other organs. This phenomenon has not been thoroughly studied in patients with trauma to date, and an association between BT and postoperative infection has not been well established so far. Methods: MLNs from 36 patients with abdominal trauma were removed during laparotomy and cultured to detect BT. Postoperative infectious complications in these patients were registered, and both phenotypical and molecular typings (through multilocus sequencing) were carried out for microorganisms isolated from MLN and postoperative infection sites. Associations between clinical variables, BT presence, and postoperative infection development were established. Results: BT was detected in 33% of the patients (n = 12). Postoperative infections were present in 22.2% of the patients (n = 8). A significant statistical difference was found between postoperative infections in patients with BT evidence (41.6%), when compared with patients without BT (12.5%; p = 0.047). Bacteria isolated from infection sites were the same as those cultured in MLN in 40% of the cases (n = 2 of 5), allowing us to establish causality between BT and postoperative infection. Conclusions: There is higher risk of BT in trauma patients, and it is associated with a significant increase of postoperative infections. An abdominal trauma index ?10 was found to be associated with the development of BT. This is the first study describing BT among patients with abdominal trauma, where causality is confirmed at molecular level. Copyright © 2011 by Lippincott Williams and Wilkins.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1097/TA.0b013e318215140e
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22486
dc.language.isoengspa
dc.relation.citationEndPage1261
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage1258
dc.relation.citationTitleJournal of Trauma - Injury
dc.relation.citationVolumeVol. 71
dc.relation.ispartofJournal of Trauma - Injury, Infection and Critical Care, Vol.71, No.5 (2011); pp. 1258-1261spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-81455144896&doi=10.1097%2fTA.0b013e318215140e&partnerID=40&md5=912c82c9b034e0411648cf7166c2bf69spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAbdominal infectionspa
dc.subject.keywordAbdominal injuryspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordBacterial translocationspa
dc.subject.keywordBacterium culturespa
dc.subject.keywordBacterium isolationspa
dc.subject.keywordClinical articlespa
dc.subject.keywordFemalespa
dc.subject.keywordHigh risk patientspa
dc.subject.keywordHumanspa
dc.subject.keywordLaparotomyspa
dc.subject.keywordMalespa
dc.subject.keywordMesentery lymph nodespa
dc.subject.keywordMolecular typingspa
dc.subject.keywordMultilocus sequence typingspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPhenotypespa
dc.subject.keywordPostoperative infectionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRespiratory tract infectionspa
dc.subject.keywordSkin infectionspa
dc.subject.keywordWound infectionspa
dc.subject.keywordAbdominal injuriesspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordBacterial translocationspa
dc.subject.keywordChi-square distributionspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordProspective studiesspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordSurgical wound infectionspa
dc.subject.keywordBacterial translocationspa
dc.subject.keywordLymph nodesspa
dc.subject.keywordPostoperative infectionsspa
dc.subject.keywordSepsisspa
dc.subject.keywordTraumaspa
dc.titleBacterial translocation in abdominal trauma and postoperative infectionsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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