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From ancient to contemporary molecular eco-epidemiology of Chagas disease in the Americas

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dc.creatorGuhl, Felipespa
dc.creatorAuderheide, Arthurspa
dc.creatorRamírez, Juan Davidspa
dc.date.accessioned2020-08-06T16:21:38Z
dc.date.available2020-08-06T16:21:38Z
dc.date.created2014spa
dc.description.abstractOne of the best-studied populations with regard to Chagas disease is from the coastal area of northern Chile at the foot of the western Andean slopes. The extremely arid climate here generates rapid, spontaneous desiccation of buried bodies, arresting the decay process. The absence of rainfall then preserves these dried bodies (mummies) for millennia. The aim of the present study was to perform the first molecular paleoepidemiological study on a set of 43 mummified human remains from the Atacama Desert in Northern Chile in order to elucidate the transmission dynamics and determinants of ancient genotypes, to try to unravel the natural history of the Trypanosoma cruzi taxon and Chagas disease. Interestingly, TcBat, a recently described Discrete Taxonomic Unit, emerges as the plausible ancestor of T. cruzi. The findings herein presented allow us to present a plausible model of T. cruzi transmission in pre-Columbian civilisations.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ijpara.2014.02.005
dc.identifier.issnISSN: 0020-7519
dc.identifier.issnEISSN: 1879-0135
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26416
dc.language.isoengspa
dc.publisherNational Center for Biotechnology Informationspa
dc.relation.citationEndPage612
dc.relation.citationIssueNo. 9
dc.relation.citationStartPage605
dc.relation.citationTitleInternational Journal for Parasitology
dc.relation.citationVolumeVol. 44
dc.relation.ispartofInternational Journal for Parasitology, ISSN: 0020-7519;EISSN: 1879-0135, Vol.44, No.9, (August, 2014); pp.605-612spa
dc.relation.urihttps://pubmed.ncbi.nlm.nih.gov/24675555/spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceInternational Journal for Parasitologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordChagas diseasespa
dc.subject.keywordFossil DNAspa
dc.subject.keywordMolecular ecoepidemiologyspa
dc.subject.keywordPaleoparasitologyspa
dc.subject.keywordPre-Columbian civilisationsspa
dc.subject.keywordTrypanosoma cruzi DTUsspa
dc.titleFrom ancient to contemporary molecular eco-epidemiology of Chagas disease in the Americasspa
dc.title.TranslatedTitleDe la ecoepidemiología molecular antigua a la contemporánea de la enfermedad de Chagas en Américaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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