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Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations

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dc.creatorSánchez, Elenaspa
dc.creatorRasmussen, Astridspa
dc.creatorRiba, Lauraspa
dc.creatorAcevedo?Vasquez, Eduardospa
dc.creatorKelly, Jennifer A.spa
dc.creatorLangefeld, Carl D.spa
dc.creatorWilliams, Adrianne H.spa
dc.creatorZiegler, Julie T.spa
dc.creatorComeau, Mary E.spa
dc.creatorMarion, Miranda C.spa
dc.creatorLa Torre, Ignacio García?Despa
dc.creatorMaradiaga?Ceceña, Marco A.spa
dc.creatorCardiel, Mario H.spa
dc.creatorEsquivel?Valerio, Jorge A.spa
dc.creatorRodriguez?Amado, Jacquelinespa
dc.creatorMoctezuma, José Franciscospa
dc.creatorMiranda, Pedrospa
dc.creatorPerandones, Carlos E.spa
dc.creatorCastel, Ceciliaspa
dc.creatorLaborde, Hugo A.spa
dc.creatorAlba, Paulaspa
dc.creatorMusuruana, Jorge L.spa
dc.creatorGoecke, I. Annelisespa
dc.creatorAnaya, Juan-Manuel
dc.creatorKaufman, Kenneth M.spa
dc.creatorAdler, Adamspa
dc.creatorGlenn, Stuart B.spa
dc.creatorBrown, Elizabeth E.spa
dc.creatorAlarcón, Graciela S.spa
dc.creatorKimberly, Robert P.spa
dc.creatorEdberg, Jeffrey C.spa
dc.creatorVilá, Luis M.spa
dc.creatorCriswell, Lindsey A.spa
dc.creatorGilkeson, Gary S.spa
dc.creatorNiewold, Timothy B.spa
dc.creatorMartín, Javierspa
dc.creatorVyse, Timothy J.spa
dc.creatorBoackle, Susan A.spa
dc.creatorRamsey?Goldman, Rosalindspa
dc.creatorScofield, R. Halspa
dc.creatorPetri, Michellespa
dc.creatorMerrill, Joan T.spa
dc.creatorReveille, John D.spa
dc.creatorTsao, Betty P.spa
dc.creatorOrozco, Lorenaspa
dc.creatorBaca, Vicentespa
dc.creatorMoser, Kathy L.spa
dc.creatorGaffney, Patrick M.spa
dc.creatorJames, Judith A.spa
dc.creatorHarley, John B.spa
dc.creatorTusié?Luna, Teresaspa
dc.creatorPons?Estel, Bernardo A.spa
dc.creatorJacob, Chaim O.spa
dc.creatorAlarcón?Riquelme, Marta E.spa
dc.date.accessioned2020-05-25T23:59:04Z
dc.date.available2020-05-25T23:59:04Z
dc.date.created2012spa
dc.description.abstractObjective American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) and a higher prevalence of lupus nephritis than do Caucasians. The aim of this study was to analyze the relationship between genetic ancestry and sociodemographic characteristics and clinical features in a large cohort of American Indian-European SLE patients. Methods A total of 2,116 SLE patients of American Indian-European origin and 4,001 SLE patients of European descent for whom we had clinical data were included in the study. Genotyping of 253 continental ancestry-informative markers was performed on the Illumina platform. Structure and Admixture software were used to determine genetic ancestry proportions of each individual. Logistic regression was used to test the association between genetic ancestry and sociodemographic and clinical characteristics. Odds ratios (ORs) were calculated with 95% confidence intervals (95% CIs). Results The average American Indian genetic ancestry of 2,116 SLE patients was 40.7%. American Indian genetic ancestry conferred increased risks of renal involvement (P less than 0.0001, OR 3.50 [95% CI 2.63- 4.63]) and early age at onset (P less than 0.0001). American Indian ancestry protected against photosensitivity (P less than 0.0001, OR 0.58 [95% CI 0.44-0.76]), oral ulcers (P less than 0.0001, OR 0.55 [95% CI 0.42-0.72]), and serositis (P less than 0.0001, OR 0.56 [95% CI 0.41-0.75]) after adjustment for age, sex, and age at onset. However, age and sex had stronger effects than genetic ancestry on malar rash, discoid rash, arthritis, and neurologic involvement. Conclusion In general, American Indian genetic ancestry correlates with lower sociodemographic status and increases the risk of developing renal involvement and SLE at an earlier age. Copyright © 2012 by the American College of Rheumatology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/art.34650
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22977
dc.language.isoengspa
dc.relation.citationEndPage3694
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage3687
dc.relation.citationTitleArthritis and Rheumatism
dc.relation.citationVolumeVol. 64
dc.relation.ispartofArthritis and Rheumatism, Vol.64, No.11 (2012); pp. 3687-3694spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84868092719&doi=10.1002%2fart.34650&partnerID=40&md5=523678b9426ee9ae333c83fa81beb18fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAfricaspa
dc.subject.keywordAmerican Indianspa
dc.subject.keywordArthritisspa
dc.subject.keywordArticlespa
dc.subject.keywordAsianspa
dc.subject.keywordDemographyspa
dc.subject.keywordDiscoid rashspa
dc.subject.keywordEuropespa
dc.subject.keywordGenetic analysisspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenetic screeningspa
dc.subject.keywordGenotyping techniquespa
dc.subject.keywordHematologic diseasespa
dc.subject.keywordHeredityspa
dc.subject.keywordHumanspa
dc.subject.keywordInflammationspa
dc.subject.keywordKidney diseasespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalar rashspa
dc.subject.keywordMouth ulcerspa
dc.subject.keywordNeurologic diseasespa
dc.subject.keywordOnset agespa
dc.subject.keywordPhotosensitivityspa
dc.subject.keywordPopulation geneticsspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordSkin diseasespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordChildspa
dc.subject.keywordEuropean Continental Ancestry Groupspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordIndianseng
dc.subject.keywordIndianseng
dc.subject.keywordLupus Erythematosuseng
dc.subject.keywordLupus Nephritisspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordMorbidityspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRisk Factorsspa
dc.subject.keywordSocioeconomic Factorsspa
dc.subject.keywordYoung Adultspa
dc.titleImpact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populationsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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