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A B-lymphocyte binding peptide from BNRF1 induced antibodies inhibiting EBV-invasion of B-lymphocytes

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dc.creatorLópez, Ramsésspa
dc.creatorUrquiza, Mauriciospa
dc.creatorPatino, Helenaspa
dc.creatorSuárez, Jorgespa
dc.creatorReyes, Claudiaspa
dc.creatorPatarroyo, Manuel A.spa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-08-06T16:20:07Z
dc.date.available2020-08-06T16:20:07Z
dc.date.created2005-11spa
dc.description.abstractEpstein–Barr virus (EBV) infects human target cells mainly through gp350/220-CD21 and gp42-MHCII interactions; however, it has been shown that these interactions are dispensable for EBV-invasion of susceptible cells, suggesting that other viral proteins are involved in this process. It is probable that tegument BNRF1/p140 protein is involved in EBV-invasion of target cells, since anti-p140 antibodies inhibit EBV-infection of B-lymphocytes and there is evidence that part of the protein is located on virus surface. Sixty-six peptides, covering the entire BNRF1/p140 sequence, were synthesised and tested in lymphoblastoid cell line binding assays. Peptides 11465 and 11521 bound with high affinity to Raji, Ramos and P3HR-1 cells but not to erythrocytes, showing cell-binding behaviour similar to EBV. These two peptides induced antibodies recognising live EBV-infected cells. Interestingly, peptide-11521 (YVLQNAHQIACHFHSNGTDA) or antibodies induced by this peptide inhibited EBV-binding to B-lymphocytes, suggesting that this p140-region could be involved in EBV and B-lymphocyte interaction.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.biochi.2005.04.009
dc.identifier.issnISSN: 0300-9084
dc.identifier.issnEISSN: 6183-1638
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25880
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage992
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage985
dc.relation.citationTitleBiochimie
dc.relation.citationVolumeVol. 87
dc.relation.ispartofBiochimie, ISSN: 0300-9084;EISSN: 6183-1638, Vol. 87 No.11 (2005); pp.985-992spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0300908405001057?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceBiochimiespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordEBVspa
dc.subject.keywordp140spa
dc.subject.keywordHABPspa
dc.subject.keywordB-lymphocytespa
dc.titleA B-lymphocyte binding peptide from BNRF1 induced antibodies inhibiting EBV-invasion of B-lymphocytesspa
dc.title.TranslatedTitleUn péptido de unión a linfocitos B de anticuerpos inducidos por BNRF1 que inhiben la invasión de linfocitos B por el EBVspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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