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Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants

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dc.creatorCaicedo Dorado, Alexander
dc.creatorAlderliesten, Thomasspa
dc.creatorNaulaers, Gunnarspa
dc.creatorLemmers, Petraspa
dc.creatorVan Bel, Frankspa
dc.creatorVan Huffel, Sabinespa
dc.date.accessioned2020-08-28T15:49:58Z
dc.date.available2020-08-28T15:49:58Z
dc.date.created2013-06-04spa
dc.description.abstractHypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO2 by means of correlation, coherence, and transfer function analysis. We found that these infants presented higher values of transfer function gain, which indicates impaired cerebral autoregulation, with a decreasing trend towards normality. We hypothesised that this trend was due to a vasodilation effect of the maternal use of labetalol due to accumulation, which disappeared by the third day after birth. Therefore, we investigated the values of pulse pressure in order to find evidence for a vasodilatory effect. We found that lower values of pulse pressure were present in these infants when compared with a control population, which, together with increased transfer function gain values, suggests an effect of the drug on the cerebral autoregulation.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/978-1-4614-7411-1_15
dc.identifier.issnISBN: 978-1-4614-7256-8
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28873
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage111
dc.relation.citationStartPage105
dc.relation.citationTitleAdvances in Experimental Medicine and Biology
dc.relation.citationVolumeVol. 789
dc.relation.ispartofAdvances in Experimental Medicine and Biology, ISBN: 978-1-4614-7256-8, Vol.789 (2013); pp. 105-111spa
dc.relation.urihttps://link.springer.com/chapter/10.1007/978-1-4614-7411-1_15spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceAdvances in Experimental Medicine and Biologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPulse Pressurespa
dc.subject.keywordMean Arterial Blood Pressurespa
dc.subject.keywordCerebral Autoregulationspa
dc.subject.keywordCerebral Blood Flow Velocityspa
dc.subject.keywordTransfer Function Analysisspa
dc.titleEffect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infantsspa
dc.title.TranslatedTitleEfecto del uso materno de labetalol sobre la autorregulación cerebral en lactantes prematurosspa
dc.typebookParteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaParte de librospa
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