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Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.

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dc.creatorAlaba, Martha Patriciaspa
dc.creatorSalazar, Luz Maryspa
dc.creatorPurmova, Jindraspa
dc.creatorVanegas, Magnoliaspa
dc.creatorRodriguez, Raulspa
dc.creatorPatarroyo, Manuel Elkinspa
dc.date.accessioned2020-08-19T14:44:19Z
dc.date.available2020-08-19T14:44:19Z
dc.date.created2004spa
dc.description.abstractThe protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in Aotus monkeys, together with several of its analogues. These peptides were studied by 1H NMR to try to correlate their structure with their biological function. These peptides showed helical regions having differences in their position, except for randomly structured 6725. It is shown that replacing some amino acids induced immunogenicity and protectivity against experimental malaria and changed their three-dimensional (3D) structure, suggesting that such modifications may allow a better fit with immune system molecules.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2003.08.046
dc.identifier.issnISSN: 0264-410X
dc.identifier.issnEISSN: 1873-2518
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27865
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage1289
dc.relation.citationIssueNo. 9-10
dc.relation.citationStartPage1281
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 22
dc.relation.ispartofVaccine, ISSN: 0264-410X ;EISSN: 1873-2518, vol.22, No.9-10 (March 2004); pp. 1281-1289spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0264410X03006819spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceVaccinespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPeptidespa
dc.subject.keywordMalariaspa
dc.subject.keywordSERAspa
dc.subject.keywordNMRspa
dc.titleInduction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.spa
dc.title.TranslatedTitleLa inducción y el desplazamiento de una hélice en el análogo del péptido SERA 6725 confiere protección contra la malaria por P. falciparum.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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