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Plasmodium vivax: Polymorphism in the Merozoite Surface Protein 1 Gene from Wild Colombian Isolates

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dc.creatorVanegas, Magnoliaspa
dc.creatorTovar, Dianaspa
dc.creatorLópez, Ramsesspa
dc.creatorPuentes, ALvarospa
dc.creatorGarcía, Javierspa
dc.creatorOcampo, Marisol
dc.date.accessioned2020-08-19T14:40:10Z
dc.date.available2020-08-19T14:40:10Z
dc.date.created2000spa
dc.description.abstractGutierrez, A., Vicini, J., Patarroyo, M. E., Murillo, L. A., and Patarroyo, M. A. 2000. Plasmodium vivax: Polymorphism in the merozoite surface protein 1 gene from wild colombian isolates. Experimental Parasitology95, 215–219. The Plasmodium vivax merozoite surface protein-1 (PvMSP-1) has been considered a candidate for a malaria vaccine against erythrocytic stages. PvMSP-1 is immunogenic during natural infections and exhibits antigenic polymorphism. The extent of genetic polymorphism in a region between the so-called interspecies conserved blocks (ICBs) 2 and 4 of the PvMSP-1 was analyzed in 20 isolates taken from patients from two different areas in Colombia. Variation is unevenly distributed along this gene segment among the isolates. Comparative analysis of these sequences led to the definition of five sequence types (ST1 to 5). ST1 to ST4 exhibit a variation pattern associated with sequences present in the Salvador or Belem sequences. However, ST5 has clusters of sequence that have not been previously described. The changes found along the five variants confirm the important role of recombinational and/or gene conversion events in generating allelic diversity.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1006/expr.2000.4534
dc.identifier.issnISSN: 0014-4894
dc.identifier.issnEISSN: 1090-2449
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26743
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage219
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage215
dc.relation.citationTitleExperimental Parasitology
dc.relation.citationVolumeVol. 95
dc.relation.ispartofExperimental Parasitology, ISSN: 0014-4894; EISSN: 1090-2449, Vol.95, No.3 (July 200); pp. 215-219 spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S001448940094534X?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceExperimental Parasitologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPolymorphismspa
dc.subject.keywordRecombinationspa
dc.subject.keywordMerozoite surface protein 1 (MSP-1)spa
dc.subject.keywordPolymerase chain reaction (PCR)spa
dc.subject.keywordInterspecies conserved block (ICB)spa
dc.subject.keywordConserved block (CB)spa
dc.subject.keywordSequence type (ST)spa
dc.subject.keywordSalvador 1 sequence (Sal-1)spa
dc.subject.keywordBelem sequence (Bel).spa
dc.titlePlasmodium vivax: Polymorphism in the Merozoite Surface Protein 1 Gene from Wild Colombian Isolatesspa
dc.title.TranslatedTitlePlasmodium vivax: polimorfismo en el gen de la proteína 1 de superficie de merozoitos de aislados colombianos silvestresspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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