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Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

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dc.creatorPacheco Nieva, Yovana
dc.creatorBarahona-Correa, Juliánspa
dc.creatorMonsalve, Diana M.spa
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorRojas, Manuelspa
dc.creatorRodríguez, Yhojanspa
dc.creatorSaavedra, Julianaspa
dc.creatorRodríguez-Jímenez, Mónica
dc.creatorMantilla, Rubén D.spa
dc.creatorRamirez-Santana, Carolinaspa
dc.creatorMolano-González, Nicolas
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-25T23:56:41Z
dc.date.available2020-05-25T23:56:41Z
dc.date.created2017spa
dc.description.abstractBackground: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed. Methods: This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile, and a panel of 15 serum cytokines were measured simultaneously. Mixed-cluster methodology and bivariate analyses were used to define autoantibody and cytokine clusters and to identify associations between them and related variables. Results: First, three clusters of autoantibodies were defined: (1) neutral, (2) antiphospholipid antibodies (APLA)-dominant, and (3) anti-dsDNA/ENA-dominant. Second, eight cytokines showed levels above the threshold thus making possible to find 4 clusters: (1) neutral, (2) chemotactic, (3) G-CSF dominant, and (4) IFN?/Pro-inflammatory. Furthermore, the disease activity was associated with cytokine clusters, which, in turn, were associated with autoantibody clusters. Finally, when all biomarkers were included, three clusters were found: (1) neutral, (2) chemotactic/APLA, and (3) IFN/dsDNA, which were also associated with disease activity. Conclusion: These results support the existence of three SLE cytokine-autoantibody driven subphenotypes. They encourage the practice of personalized medicine, and support proof-of-concept studies. © 2017 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12967-017-1345-y
dc.identifier.issn14795876
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22483
dc.language.isoengspa
dc.publisherBioMed Central Ltd.spa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleJournal of Translational Medicine
dc.relation.citationVolumeVol. 15
dc.relation.ispartofJournal of Translational Medicine, ISSN:14795876, Vol.15, No.1 (2017)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85034807897&doi=10.1186%2fs12967-017-1345-y&partnerID=40&md5=678b14b476b02ecd84c8841f1bfae4f9spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAlpha interferonspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordsystemiceng
dc.subject.keywordantinucleareng
dc.subject.keywordBiological markerspa
dc.subject.keywordCytokinespa
dc.subject.keywordCytokine antibodyspa
dc.subject.keywordDouble stranded dna antibodyspa
dc.subject.keywordGranulocyte colony stimulating factorspa
dc.subject.keywordPhospholipid antibodyspa
dc.subject.keywordAntinuclear antibodyspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordCytokinespa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDisease activityspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPersonalized medicinespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordBloodspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAdultspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordCytokinesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordMiddle agedspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAnti-dsdna antibodiesspa
dc.subject.keywordAntiphospholipid antibodiesspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordCytokinesspa
dc.subject.keywordInterferon alphaspa
dc.subject.keywordInterleukin 12p40spa
dc.subject.keywordInterleukin 8spa
dc.subject.keywordPersonalized medicinespa
dc.subject.keywordSubphenotypesspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordTaxonomyspa
dc.titleCytokine and autoantibody clusters interaction in systemic lupus erythematosusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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