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Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorCastiblanco J.spa
dc.creatorTobón G.J.spa
dc.creatorGarcía J.spa
dc.creatorAbad V.spa
dc.creatorCuervo H.spa
dc.creatorVelásquez A.spa
dc.creatorAngel I.D.spa
dc.creatorVega P.spa
dc.creatorArango A.spa
dc.date.accessioned2020-05-25T23:55:52Z
dc.date.available2020-05-25T23:55:52Z
dc.date.created2006spa
dc.description.abstractWe investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. © 2006 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2006.01.001
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22247
dc.language.isoengspa
dc.relation.citationEndPage214
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage208
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 26
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.26, No.3 (2006); pp. 208-214spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33646681230&doi=10.1016%2fj.jaut.2006.01.001&partnerID=40&md5=a0ccaf1c6ad42a5eba4f3bcb7b20dce4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdolescentspa
dc.subject.keywordtype 1eng
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordChildspa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDemographyspa
dc.subject.keywordFamily relationspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic analysisspa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPedigreespa
dc.subject.keywordPriority journalspa
dc.subject.keywordQuestionnairespa
dc.subject.keywordThyroid diseasespa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordChildspa
dc.subject.keywordDiabetes mellituseng
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordPedigreespa
dc.subject.keywordAggregationspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHypothyroidismspa
dc.subject.keywordType 1 diabetes mellitusspa
dc.titleFamilial clustering of autoimmune diseases in patients with type 1 diabetes mellitusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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