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Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population

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dc.creatorTobon G.J.spa
dc.creatorArango A.spa
dc.creatorAbad V.spa
dc.creatorGarcía J.spa
dc.creatorCuervo H.spa
dc.creatorVelásquez A.spa
dc.creatorAngel I.D.spa
dc.creatorVega P.spa
dc.creatorAbad A.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:06:01Z
dc.date.available2020-05-26T00:06:01Z
dc.date.created2006spa
dc.description.abstractWe underwent a project aimed to define the clinical and immunological characteristics of type 1 diabetes (T1D) in a Colombian population. This was a multicenter and cross-sectional study. Patients were systematically interviewed and their medical records reviewed, using a questionnaire that sought information about demographic, clinical and immunological characteristics. Glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A) and insulin antibodies (IAA) were examined by radioimmunoassay. There were 107 patients with T1D. Male:female ratio was 1:1. Half of the patients developed diabetes ketoacidosis at onset. GADA, IA-2A, and IAA were detected in 45%, 40%, and 69% of the cases, respectively. GADA positive patients were older and had a less duration of disease than patients without these autoantibodies (p less than 0.01). Association between breast feeding with the presence of antibodies or clinical characteristics was not observed. The results highlight some differences of T1D expression according to geographic location and ethnicity. Differences in age at onset and clinical variables may point to an environmental factor or deficient access to health care system. Genetic studies underway will provide important information in this population. These results might help to define public health policies in our population to improve T1D diagnosis, patients' quality of life and their outcome. © 2005 Elsevier Ireland Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.diabres.2005.10.016
dc.identifier.issn1688227
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23849
dc.language.isoengspa
dc.relation.citationEndPage175
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage170
dc.relation.citationTitleDiabetes Research and Clinical Practice
dc.relation.citationVolumeVol. 72
dc.relation.ispartofDiabetes Research and Clinical Practice, ISSN:1688227, Vol.72, No.2 (2006); pp. 170-175spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33646160994&doi=10.1016%2fj.diabres.2005.10.016&partnerID=40&md5=42ae201b7d18719ee45ed96ffa6c8279spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntibodyspa
dc.subject.keywordtype 1eng
dc.subject.keywordAutoantibodyspa
dc.subject.keywordGlutamate decarboxylase antibodyspa
dc.subject.keywordInsulin antibodyspa
dc.subject.keywordTyrosine phosphatase antibodyspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordBreast feedingspa
dc.subject.keywordChildspa
dc.subject.keywordClinical featurespa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDemographyspa
dc.subject.keywordDiabetic ketoacidosisspa
dc.subject.keywordDisease durationspa
dc.subject.keywordEthnologyspa
dc.subject.keywordFemalespa
dc.subject.keywordGeographyspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunologyspa
dc.subject.keywordInfantspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMedical recordspa
dc.subject.keywordOnset agespa
dc.subject.keywordQuestionnairespa
dc.subject.keywordRadioimmunoassayspa
dc.subject.keywordSex differencespa
dc.subject.keywordAdultspa
dc.subject.keywordAge of onsetspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordDiabetes mellituseng
dc.subject.keywordDiabetic ketoacidosisspa
dc.subject.keywordFemalespa
dc.subject.keywordGlutamate decarboxylasespa
dc.subject.keywordHumansspa
dc.subject.keywordInsulin antibodiesspa
dc.subject.keywordMalespa
dc.subject.keywordProtein-tyrosine-phosphatasespa
dc.subject.keywordColombiaspa
dc.subject.keywordGadaspa
dc.subject.keywordIa-2aspa
dc.subject.keywordIaaspa
dc.subject.keywordType 1 diabetesspa
dc.titleClinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian populationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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