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PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

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dc.creatorvan Setten, Jessica
dc.creatorBrody, Jennifer A.
dc.creatorJamshidi, Yalda
dc.creatorSwenson, Brenton R.
dc.creatorButler, Anne M.
dc.creatorCampbell, Harry
dc.creatorDel Greco, Fabiola M.
dc.creatorEvans, Daniel S.
dc.creatorGibson, Quince
dc.creatorGudbjartsson, Daniel F.
dc.creatorKerr, Kathleen
dc.creatorKrijthe, Bouwe P.
dc.creatorLyytikäinen, Leo-Pekka
dc.creatorMüller, Christian
dc.creatorMüller-Nurasyid, Martina
dc.creatorNolte, Ilja M.
dc.creatorPadmanabhan, Sandosh
dc.creatorRitchie, Marylyn D.
dc.creatorRobino, Antonietta
dc.creatorSmith, Albert V.
dc.creatorSteri, Maristella
dc.creatorTanaka, Toshiko
dc.creatorTeumer, Alexander
dc.creatorTrompet, Stella
dc.creatorUlivi, Sheila
dc.creatorVerweij, Niek
dc.creatorYin, Xiaoyan
dc.creatorArnar, David O.
dc.creatorAsselbergs, Folkert W.
dc.creatorBader, Joel S.
dc.creatorBarnard, John
dc.creatorBis, Josh
dc.creatorBlankenberg, Stefan
dc.creatorBoerwinkle, Eric
dc.creatorBradford, Yuki
dc.creatorBuckley, Brendan M.
dc.creatorChung, Mina K.
dc.creatorCrawford, Dana
dc.creatorden Hoed, Marcel
dc.creatorDenny, Josh C.
dc.creatorDominiczak, Anna F.
dc.creatorEhret, Georg B.
dc.creatorEijgelsheim, Mark
dc.creatorEllinor, Patrick T.
dc.creatorFelix, Stephan B.
dc.creatorFranco, Oscar H.
dc.creatorFranke, Lude
dc.creatorHarris, Tamara B.
dc.creatorHolm, Hilma
dc.creatorGANDIN, ILARIA
dc.creatorIorio, Annamaria
dc.creatorKähönen, Mika
dc.creatorKolcic, Ivana
dc.creatorKors, Jan A.
dc.creatorLakatta, Edward G.
dc.creatorLauner, Lenore J.
dc.creatorLin, Honghuang
dc.creatorLin, Henry J.
dc.creatorLoos, Ruth J.F.
dc.creatorLubitz, Steven A.
dc.creatorMacfarlane, Peter W.
dc.creatorMagnani, Jared W.
dc.creatorMateo Leach, Irene
dc.creatorMeitinger, Thomas
dc.creatorMitchell, Braxton D.
dc.creatorMunzel, Thomas
dc.creatorPapanicolaou, George J.
dc.creatorPeters, Annette
dc.creatorPfeufer, Arne
dc.creatorPramstaller, Peter P.
dc.creatorRaitakari, Olli T.
dc.creatorRotter, Jerome I.
dc.creatorRudan, Igor
dc.creatorSamani, Nilesh J.
dc.creatorSchlessinger, David
dc.creatorSilva Aldana, Claudia T.
dc.creatorSinner, Moritz F.
dc.creatorSmith, Jonathan D.
dc.creatorSnieder, Harold
dc.creatorSoliman, Elsayed Z.
dc.creatorSpector, Timothy D.
dc.creatorStott, David J.
dc.creatorStrauch, Konstantin
dc.creatorTarasov, Kirill V.
dc.creatorThorsteinsdottir, Unnur
dc.creatorUitterlinden, Andre G.
dc.creatorVan Wagoner, David R.
dc.creatorVölker, Uwe
dc.creatorVölzke, Henry
dc.creatorWaldenberger, Melanie
dc.creatorWestra, Harm Jan
dc.creatorWild, Philipp S.
dc.creatorZeller, Tanja
dc.creatorAlonso, Alvaro
dc.creatorAvery, Christy L.
dc.creatorBandinelli, Stefania
dc.creatorBenjamin, Emelia J.
dc.creatorCucca, Francesco
dc.creatorDörr, Marcus
dc.creatorFerrucci, Luigi
dc.creatorGasparini, Paolo
dc.creatorGudnason, Vilmundur
dc.creatorHayward, Caroline
dc.creatorHeckbert, Susan R.
dc.creatorHicks, Andrew A.
dc.creatorJukema, J. Wouter
dc.creatorKääb, Stefan
dc.creatorLehtimäk, Terho
dc.creatorLiu, Yongmei
dc.creatorMunroe, Patricia B.
dc.creatorParsa, Afshin
dc.creatorPolasek, Ozren
dc.creatorPsaty, Bruce M.
dc.creatorRoden, Dan M.
dc.creatorSchnabel, Renate B.
dc.creatorSinagra, Gianfranco
dc.creatorStefansson, Kari
dc.creatorStricker, Bruno H.
dc.creatorHarst, Pim van der
dc.creatorDuijn, Cornelia M. van
dc.creatorWilson, James F.
dc.creatorGharib, Sina A.
dc.creatorBakker, Paul I.W. de
dc.creatorIsaacs, Aaron
dc.creatorArking, Dan E.
dc.creatorSotoodehnia, Nona
dc.creator.googlevan Setten, Jessicaspa
dc.creator.googleBrody, Jennifer A.spa
dc.creator.googleJamshidi, Yaldaspa
dc.creator.googleSwenson, Brenton R.spa
dc.creator.googleButler, Anne M.spa
dc.creator.googleCampbell, Harryspa
dc.creator.googleDel Greco, Fabiola M.spa
dc.creator.googleEvans, Daniel S.spa
dc.creator.googleGibson, Quincespa
dc.creator.googleGudbjartsson, Daniel F.spa
dc.creator.googleKerr, Kathleen F.spa
dc.creator.googleKrijthe, Bouwe P.spa
dc.creator.googleLyytikäinen, Leo-Pekkaspa
dc.creator.googleMüller, Christianspa
dc.creator.googleMüller-Nurasyid, Martinaspa
dc.creator.googleNolte, Ilja M.spa
dc.creator.googlePadmanabhan, Sandoshspa
dc.creator.googleRitchie, Marylyn D.spa
dc.creator.googleRobino, Antoniettaspa
dc.creator.googleSmith, Albert V.spa
dc.creator.googleSteri, Maristellaspa
dc.creator.googleTanaka, Toshikospa
dc.creator.googleTeumer, Alexanderspa
dc.creator.googleTrompet, Stellaspa
dc.creator.googleUlivi, Sheilaspa
dc.creator.googleVerweij, Niekspa
dc.creator.googleYin, Xiaoyanspa
dc.creator.googleArnar, David O.spa
dc.creator.googleAsselbergs, Folkert W.spa
dc.creator.googleBader, Joel S.spa
dc.creator.googleBarnard, Johnspa
dc.creator.googleBis, Joshspa
dc.creator.googleBlankenberg, Stefanspa
dc.creator.googleBoerwinkle, Ericspa
dc.creator.googleBradford, Yukispa
dc.creator.googleBuckley, Brendan M.spa
dc.creator.googleChung, Mina K.spa
dc.creator.googleCrawford, Danaspa
dc.creator.googleden Hoed, Marcelspa
dc.creator.googleDenny, Josh C.spa
dc.creator.googleDominiczak, Anna F.spa
dc.creator.googleEhret, Georg B.spa
dc.creator.googleEijgelsheim, Markspa
dc.creator.googleEllinor, Patrick T.spa
dc.creator.googleFelix, Stephan B.spa
dc.creator.googleFranco, Oscar H.spa
dc.creator.googleFranke, Ludespa
dc.creator.googleHarris, Tamara B.spa
dc.creator.googleHolm, Hilmaspa
dc.creator.googleIlaria, Gandinspa
dc.creator.googleIorio, Annamariaspa
dc.creator.googleKähönen, Mikaspa
dc.creator.googleKolcic, Ivanaspa
dc.creator.googleKors, Jan A.spa
dc.creator.googleLakatta, Edward G.spa
dc.creator.googleLauner, Lenore J.spa
dc.creator.googleLin, Honghuangspa
dc.creator.googleLin, Henry J.spa
dc.creator.googleLoos, Ruth J.F.spa
dc.creator.googleLubitz, Steven A.spa
dc.creator.googleMacfarlane, Peter W.spa
dc.creator.googleMagnani, Jared W.spa
dc.creator.googleMateo Leach, Irenespa
dc.creator.googleMeitinger, Thomasspa
dc.creator.googleMitchell, Braxton D.spa
dc.creator.googleMunzel, Thomasspa
dc.creator.googlePapanicolaou, George J.spa
dc.creator.googlePeters, Annettespa
dc.creator.googlePfeufer, Arnespa
dc.creator.googlePramstaller, Peter P.spa
dc.creator.googleRaitakari, Olli T.spa
dc.creator.googleRotter, Jerome I.spa
dc.creator.googleRudan, Igorspa
dc.creator.googleSamani, Nilesh J.spa
dc.creator.googleSchlessinger, Davidspa
dc.creator.googleSilva Aldana, Claudia T.spa
dc.creator.googleSinner, Moritz F.spa
dc.creator.googleSmith, Jonathan D.spa
dc.creator.googleSnieder, Haroldspa
dc.creator.googleSoliman, Elsayed Z.spa
dc.creator.googleSpector, Timothy D.spa
dc.creator.googleStott, David J.spa
dc.creator.googleStrauch, Konstantinspa
dc.creator.googleTarasov, Kirill V.spa
dc.creator.googleThorsteinsdottir, Unnurspa
dc.creator.googleUitterlinden, Andre G.spa
dc.creator.googleVan Wagoner, David R.spa
dc.creator.googleVölker, Uwespa
dc.creator.googleVölzke, Henryspa
dc.creator.googleWaldenberger, Melaniespa
dc.creator.googleJan Westra, Harmspa
dc.creator.googleWild, Philipp S.spa
dc.creator.googleZeller, Tanjaspa
dc.creator.googleAlonso, Alvarospa
dc.creator.googleAvery, Christy L.spa
dc.creator.googleBandinelli, Stefaniaspa
dc.creator.googleBenjamin, Emelia J.spa
dc.creator.googleCucca, Francescospa
dc.creator.googleDörr, Marcusspa
dc.creator.googleFerrucci, Luigispa
dc.creator.googleGasparini, Paolospa
dc.creator.googleGudnason, Vilmundurspa
dc.creator.googleHayward, Carolinespa
dc.creator.googleHeckbert, Susan R.spa
dc.creator.googleHicks, Andrew A.spa
dc.creator.googleJukema, J. Wouterspa
dc.creator.googleKääb, Stefanspa
dc.creator.googleLehtimäki, Terhospa
dc.creator.googleLiu, Yongmeispa
dc.creator.googleMunroe, Patricia B.spa
dc.creator.googleParsa, Afshinspa
dc.creator.googlePolasek, Ozrenspa
dc.creator.googlePsaty, Bruce M.spa
dc.creator.googleRoden, Dan M.spa
dc.creator.googleSchnabel, Renate B.spa
dc.creator.googleSinagra, Gianfrancospa
dc.creator.googleStefansson, Karispa
dc.creator.googleStricker, Bruno H.spa
dc.creator.googlevan der Harst, Pimspa
dc.creator.googlevan Duijn, Cornelia M.spa
dc.creator.googleWilson,James F.spa
dc.creator.googleGharib, Sina A.spa
dc.creator.googlede Bakker, Paul I.W.spa
dc.creator.googleIsaacs, Aaronspa
dc.creator.googleArking, Dan E.spa
dc.creator.googleSotoodehnia, Nonaspa
dc.date.accessioned2019-10-17T12:55:20Z
dc.date.available2019-10-17T12:55:20Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractElectrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of ~105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ion-channel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development. © 2018, The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1038/s41467-018-04766-9
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20449
dc.language.isoengspa
dc.relation.citationTitleNature Communications
dc.relation.citationVolumeVol. 9
dc.relation.ispartofNature Communications, ISSN:2041-1723, Vol. 9 (2018)spa
dc.relation.urihttps://www.nature.com/articles/s41467-018-04766-9spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationKannel, W.B., Benjamin, E.J., Current perceptions of the epidemiology of atrial fibrillation (2009) Cardiol. Clin., 27, pp. 13-24. , PID: 19111760spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectIon Channelspa
dc.subjectTranscription Factorspa
dc.subjectDisequilibriumspa
dc.subjectGenetic Analysisspa
dc.subjectGenomespa
dc.subjectMeta-Analysisspa
dc.subjectRisk Factorspa
dc.subjectAfricanspa
dc.subjectAtrial Fibrillationspa
dc.subjectAtrioventricular Conductionspa
dc.subjectCell Junctionspa
dc.subjectElectric Activityspa
dc.subjectEuropeanspa
dc.subjectGene Linkage Disequilibriumspa
dc.subjectGene Locusspa
dc.subjectGenome-Wide Association Studyspa
dc.subjectHeart Blockspa
dc.subjectHeart Depolarizationspa
dc.subjectHeart Ratespa
dc.subjectHumanspa
dc.subjectMissense Mutationspa
dc.subjectPhenotypespa
dc.subjectPr Intervalspa
dc.subjectQrs Intervalspa
dc.subjectSignal Transductionspa
dc.subjectCanal de ionesspa
dc.subjectFactor de transcripciónspa
dc.subjectSangrespa
dc.subjectSistema cardiovascularspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordCardiovascular systemspa
dc.subject.keywordBloodspa
dc.subject.keywordHeart Diseasespa
dc.subject.keywordArticlespa
dc.subject.lembEnfermedades cardiovascularesspa
dc.subject.lembFibrilación auricularspa
dc.subject.lembBloqueo cardíacospa
dc.titlePR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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