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Original antigenic sin: A comprehensive review

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dc.creatorVatti A.spa
dc.creatorMonsalve Carmona, Diana Marcelaspa
dc.creatorPacheco Y.spa
dc.creatorChang C.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorGershwin M.E.spa
dc.date.accessioned2020-05-25T23:55:54Z
dc.date.available2020-05-25T23:55:54Z
dc.date.created2017spa
dc.description.abstractThe concept of “original antigenic sin” was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infections and its mechanistic implications on how vaccines should be designed. Antigenic sin has been demonstrated to occur in several infectious diseases in both animals and humans, including human influenza infection and dengue fever. The basis of “original antigenic sin” requires immunological memory, and our immune system ability to autocorrect. In the context of viral infections, it is expected that if we are exposed to a native strain of a pathogen, we should be able to mount a secondary immune response on subsequent exposure to the same pathogen. “Original antigenic sin” will not contradict this well-established immunological process, as long as the subsequent infectious antigen is identical to the original one. But “original antigenic sin” implies that when the epitope varies slightly, then the immune system relies on memory of the earlier infection, rather than mount another primary or secondary response to the new epitope which would allow faster and stronger responses. The result is that the immunological response may be inadequate against the new strain, because the immune system does not adapt and instead relies on its memory to mount a response. In the case of vaccines, if we only immunize to a single strain or epitope, and if that strain/epitope changes over time, then the immune system is unable to mount an accurate secondary response. In addition, depending of the first viral exposure the secondary immune response can result in an antibody-dependent enhancement of the disease or at the opposite, it could induce anergy. Both of them triggering loss of pathogen control and inducing aberrant clinical consequences. © 2017 Elsevier Ltdeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2017.04.008
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22259
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationEndPage21
dc.relation.citationStartPage12
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 83
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.83,(2017); pp. 12-21spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85018263565&doi=10.1016%2fj.jaut.2017.04.008&partnerID=40&md5=19da9523910b9a26f1e8fe15b4794e26spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntigenspa
dc.subject.keywordhumoraleng
dc.subject.keywordimmunologicaleng
dc.subject.keywordEpitopespa
dc.subject.keywordVaccinespa
dc.subject.keywordAntigenspa
dc.subject.keywordAntibody dependent enhancementspa
dc.subject.keywordChlamydia trachomatisspa
dc.subject.keywordDengue virusspa
dc.subject.keywordEnterovirusspa
dc.subject.keywordHuman bocavirusspa
dc.subject.keywordHuman immunodeficiency virusspa
dc.subject.keywordHumoral immunityspa
dc.subject.keywordImmune responsespa
dc.subject.keywordInfluenza virusspa
dc.subject.keywordLeptospirosisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodiumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordSecondary immune responsespa
dc.subject.keywordZika virusspa
dc.subject.keywordAnimalspa
dc.subject.keywordBiological modelspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunological memoryspa
dc.subject.keywordImmunological tolerancespa
dc.subject.keywordImmunologyspa
dc.subject.keywordInfectionspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigensspa
dc.subject.keywordHumansspa
dc.subject.keywordImmune tolerancespa
dc.subject.keywordImmunityeng
dc.subject.keywordImmunodominant epitopesspa
dc.subject.keywordImmunologic memoryspa
dc.subject.keywordInfectionspa
dc.subject.keywordModelseng
dc.subject.keywordVaccinesspa
dc.subject.keywordAntibody-dependent enhancementspa
dc.subject.keywordBocavirusspa
dc.subject.keywordDenguespa
dc.subject.keywordInfluenzaspa
dc.subject.keywordMemory immune responsespa
dc.subject.keywordVaccinationspa
dc.subject.keywordZika virusspa
dc.titleOriginal antigenic sin: A comprehensive reviewspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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