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Human papillomavirus (HPV69/HPV73) coinfection associated with simultaneous squamous cell carcinoma of the anus and presumed lung metastasis

dc.creatorShea, Stephaniespa
dc.creatorMuñoz, Marinaspa
dc.creatorWard, Stephen C.spa
dc.creatorBeasley, Mary B.spa
dc.creatorGitman, Melissa Rspa
dc.creatorNowak, Michael Dspa
dc.creatorHouldsworth, Janespa
dc.creatorSordillo, Emilia Miaspa
dc.creatorRamírez, Juan David
dc.creatorMondolfi, Alberto E. Panizspa
dc.date.accessioned2020-05-26T00:02:21Z
dc.date.available2020-05-26T00:02:21Z
dc.date.created2020spa
dc.description.abstractBackground: Human papillomaviruses (HPVs) have been linked to a variety of human cancers. As the landscape of HPV-related neoplasia continues to expand, uncommon and rare HPV genotypes have also started to emerge. Host-virus interplay is recognized as a key driver in HPV carcinogenesis, with host immune status, virus genetic variants and coinfection highly influencing the dynamics of malignant transformation. Immunosuppression and tissue tropism are also known to influence HPV pathogenesis. Methods: Herein, we present a case of a patient who, in the setting of HIV positivity, developed anal squamous cell carcinoma associated with HPV69 and later developed squamous cell carcinoma in the lungs, clinically presumed to be metastatic disease, associated with HPV73. Consensus PCR screening for HPV was performed by real-time PCR amplification of the L1 gene region, amplification of the E6 regions with High-Resolution Melting Curve Analysis followed by Sanger sequencing confirmation and phylogenetic analysis. Results: Sanger sequencing of the consensus PCR amplification product determined that the anal tissue sample was positive for HPV 69, and the lung tissue sample was positive for HPV 73. Conclusions: This case underscores the importance of recognizing the emerging role of these rare 'possibly carcinogenic' HPV types in human carcinogenesis. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/v12030349
dc.identifier.issn19994915
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23476
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 3
dc.relation.citationTitleViruses
dc.relation.citationVolumeVol. 12
dc.relation.ispartofViruses, ISSN:19994915, Vol.12, No.3 (2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85082515888&doi=10.3390%2fv12030349&partnerID=40&md5=5c61f73551dc58d30ff5be48051798efspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCase reportspa
dc.subject.keywordCarcinogenesisspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordHpv69spa
dc.subject.keywordHpv73spa
dc.subject.keywordHuman papillomavirusesspa
dc.titleHuman papillomavirus (HPV69/HPV73) coinfection associated with simultaneous squamous cell carcinoma of the anus and presumed lung metastasisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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