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How do autoimmune diseases cluster in families? A systematic review and meta-analysis

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dc.audienceComunidad Rosaristaspa
dc.creatorCardenas Roldan, Jorge
dc.creatorRojas-Villarraga, Adriana
dc.creatorAnaya, Juan-Manuel
dc.creator.googleCardenas Roldan, Jorge
dc.creator.googleRojas-Villarraga, Adriana
dc.creator.googleAnaya, Juan-Manuel
dc.date.accessioned2014-08-12T15:21:38Z
dc.date.available2014-08-12T15:21:38Z
dc.date.created2013-03
dc.date.issued2013
dc.description.abstractBackground: A primary characteristic of complex genetic diseases is that affected individuals tend to cluster in families (that is, familial aggregation). Aggregation of the same autoimmune condition, also referred to as familial autoimmune disease, has been extensively evaluated. However, aggregation of diverse autoimmune diseases, also known as familial autoimmunity, has been overlooked. Therefore, a systematic review and meta-analysis were performed aimed at gathering evidence about this topic. Methods: Familial autoimmunity was investigated in five major autoimmune diseases, namely, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid disease, multiple sclerosis and type 1 diabetes mellitus. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed. Articles were searched in Pubmed and Embase databases. Results: Out of a total of 61 articles, 44 were selected for final analysis. Familial autoimmunity was found in all the autoimmune diseases investigated. Aggregation of autoimmune thyroid disease, followed by systemic lupus erythematosus and rheumatoid arthritis, was the most encountered. Conclusions: Familial autoimmunity is a frequently seen condition. Further study of familial autoimmunity will help to decipher the common mechanisms of autoimmunity.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.issnISSN:1741-7015
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8804
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 73
dc.relation.citationTitleBMC MEDICINE
dc.relation.citationVolumeVol. 11
dc.relation.ispartofBMC MEDICINE ISSN: 1741-7015 V. 11 N. 73 Mar, 2013spa
dc.relation.urihttp://www.biomedcentral.com/content/pdf/1741-7015-11-73.pdf
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcIncidencia & prevención de la enfermedad
dc.subject.decsEsclerosis múltiplespa
dc.subject.decsDiabetes mellitusspa
dc.subject.decsLupus eritematoso sistémicospa
dc.subject.decsEnfermedades infecciosasspa
dc.subject.decsInmunologíaspa
dc.subject.keywordRheumatoid-Arthritis familieseng
dc.subject.keywordPrimary sjogrens syndromeeng
dc.subject.keywordType-1 diabetes mellituseng
dc.subject.keywordMultiple sclerosiseng
dc.subject.keywordLupus erythematosuseng
dc.subject.keyword1st-degree relativeseng
dc.subject.keywordCeliac diseaseeng
dc.subject.keywordJuvenile dermatomyositiseng
dc.subject.keywordIncreased prevalenceeng
dc.subject.keywordAdditional aspectseng
dc.titleHow do autoimmune diseases cluster in families? A systematic review and meta-analysiseng
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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