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Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis

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dc.creatorGomez L.M.spa
dc.creatorCamargo J.F.spa
dc.creatorCastiblanco J.spa
dc.creatorRuiz-Narváez E.A.spa
dc.creatorCadena J.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:01:35Z
dc.date.available2020-05-26T00:01:35Z
dc.date.created2006spa
dc.description.abstractGenetic determinants of human susceptibility to tuberculosis (TB) have not been completely elucidated. Interleukin-1 beta (IL-1?) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a broad spectrum of infectious agents. The transporter associated with antigen processing (TAP) is involved in the antigen processing via major histocompatibility complex class I molecules and in turn might regulate the T-cell response against Mycobacterium tuberculosis. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of functional polymorphisms in IL1B, TAP and IKBL genes on the risk of developing pulmonary TB in a Northwestern Colombian population, an endemic area of M. tuberculosis infection. A total of 122 TB patients and 166 healthy controls (N = 166) negative for human immunodeficiency virus infection were examined for IL1B-511 and +3953, TAP1 and TAP2 and IKBL+738 polymorphisms. Univariate analysis disclosed significant differences between patients and controls for IL1B+3953 polymorphism. After unconditional logistic regression analysis, a strong protection conferred by IL1B+3953 T-allele-carrying genotypes was observed. A trend between TAP2*0201 allele and disease was observed. Association between IL1B-511, TAP1 or IKBL polymorphisms and TB disease was not found. These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1? in the pathogenesis of mycobacterial infection. © 2006 Blackwell Munksgaard.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1399-0039.2006.00566.x
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23385
dc.language.isoengspa
dc.relation.citationEndPage296
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage290
dc.relation.citationTitleTissue Antigens
dc.relation.citationVolumeVol. 67
dc.relation.ispartofTissue Antigens, Vol.67, No.4 (2006); pp. 290-296spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33646079376&doi=10.1111%2fj.1399-0039.2006.00566.x&partnerID=40&md5=ac1cb65c0c62df77d8f840262ee90df4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordI kappa Bspa
dc.subject.keywordPulmonaryeng
dc.subject.keywordSingle Nucleotideeng
dc.subject.keywordImmunoglobulin enhancer binding proteinspa
dc.subject.keywordInterleukin 1betaspa
dc.subject.keywordTransporter associated with antigen processing 1spa
dc.subject.keywordTransporter associated with antigen processing 2spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordArticlespa
dc.subject.keywordCase control studyspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenotypespa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordTuberculosisspa
dc.subject.keywordAdultspa
dc.subject.keywordATP-Binding Cassette Transportersspa
dc.subject.keywordCase-Control Studiesspa
dc.subject.keywordDisease Susceptibilityspa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHistocompatibility Antigens Class IIspa
dc.subject.keywordHumansspa
dc.subject.keywordInterleukin-1spa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordTuberculosiseng
dc.subject.keywordHuman immunodeficiency virusspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHost-guest interactionspa
dc.subject.keywordIKBLspa
dc.subject.keywordIL1Bspa
dc.subject.keywordTAPspa
dc.subject.keywordTuberculosisspa
dc.titleAnalysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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