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Cytokine profiling in chagas disease: towards understanding the association with infecting Trypanosoma cruzi discrete typing units (a benefit trial sub-study)

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dc.creatorPoveda, Cristinaspa
dc.creatorFresno, Manuelspa
dc.creatorGironès, Núriaspa
dc.creatorMartins-Filho, Olindo A.spa
dc.creatorRamírez, Juan Davidspa
dc.creatorSanti-Rocca, Julienspa
dc.creatorMarin-Neto, José A.spa
dc.creatorMorillo, Carlos A.spa
dc.creatorRosas, Fernandospa
dc.creatorGuhl, Felipespa
dc.date.accessioned2020-08-19T14:42:17Z
dc.date.available2020-08-19T14:42:17Z
dc.date.created2014-03-07spa
dc.description.abstractBackground Chagas disease caused by the protozoan Trypanosoma cruzi is an important public health problem in Latin America. The immunological mechanisms involved in Chagas disease pathogenesis remain incompletely elucidated. The aim of this study was to explore cytokine profiles and their possible association to the infecting DTU and the pathogenesis of Chagas disease. Methods 109 sero-positive T. cruzi patients and 21 negative controls from Bolivia and Colombia, were included. Flow cytometry assays for 13 cytokines were conducted on human sera. Patients were divided into two groups: in one we compared the quantification of cytokines between patients with and without chronic cardiomyopathy; in second group we compared the levels of cytokines and the genetic variability of T. cruzi. Results Significant difference in anti-inflammatory and pro-inflammatory cytokines profiles was observed between the two groups cardiac and non-cardiac. Moreover, serum levels of IFN-?, IL-12, IL-22 and IL-10 presented an association with the genetic variability of T.cruzi, with significant differences in TcI and mixed infections TcI/TcII. Conclusion Expression of anti-inflammatory and pro-inflammatory cytokines may play a relevant role in determining the clinical presentation of chronic patients with Chagas disease and suggests the occurrence of specific immune responses, probably associated to different T. cruzi DTUs.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0091154
dc.identifier.issnEISSN: 1932-6203
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27460
dc.language.isoengspa
dc.publisherPLOS Public Library of Sciencespa
dc.relation.citationIssueNo. 3
dc.relation.citationStartPageE91154
dc.relation.citationTitlePLoS One
dc.relation.citationVolumeVol. 9
dc.relation.ispartofPLoS One, EISSN: 1932-6203, Vol.9, No.3 (March 2014); pp. E91154spa
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0091154&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourcePLoS Onespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordCytokinesspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordCardiomyopathiesspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordImmune responsespa
dc.subject.keywordProtozoan infectionsspa
dc.subject.keywordParasitic diseasesspa
dc.titleCytokine profiling in chagas disease: towards understanding the association with infecting Trypanosoma cruzi discrete typing units (a benefit trial sub-study)spa
dc.title.TranslatedTitlePerfiles de citocinas en la enfermedad de Chagas: hacia la comprensión de la asociación con unidades de tipificación discretas de Trypanosoma cruzi infecciosas (un subestudio de ensayo de beneficios)spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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