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Outcome of patients with autoimmune diseases in the intensive care unit : A mixed cluster analysis

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dc.creatorBernal-Macías, Santiago
dc.creatorReyes-Beltran, Benjamin
dc.creatorMolano González, Nicolás
dc.creatorVega, Daniel Augusto
dc.creatorBichernal, Claudia
dc.creatorDíaz, Luis Aurelio
dc.creatorRojas-Villarraga, Adriana
dc.creatorAnaya, Juan-Manuel
dc.creator.googleBernal-Macías, Santiagospa
dc.creator.googleReyes-Beltran, Benjaminspa
dc.creator.googleMolano-González, Nicolasspa
dc.creator.googleVega, Daniel Augustospa
dc.creator.googleBichernal, Claudiaspa
dc.creator.googleDíaz, Luis Aureliospa
dc.creator.googleRojas-Villarraga, Adrianaspa
dc.creator.googleAnaya, Juan-Manuelspa
dc.date.accessioned2019-03-07T16:37:19Z
dc.date.available2019-03-07T16:37:19Z
dc.date.created2015
dc.date.issued2015
dc.description.abstractObjectives: The interest on autoimmune diseases (ADs) and their outcome at the intensive care unit (ICU) has increased due to the clinical challenge for diagnosis and management as well as for prognosis. The current work presents a-year experience on these topics in a tertiary hospital. Methods: The mixed-cluster methodology based on multivariate descriptive methods such as principal component analysis and multiple correspondence analyses was performed to summarize sets of related variables with strong associations and common clinical context. Results: Fifty adult patients with ADs with a mean age of 46.7±17.55 years were assessed. The two most common diagnoses were systemic lupus erythematosus and systemic sclerosis, registered in 45% and 20% of patients, respectively. The main causes of admission to ICU were infection and AD flare up, observed in 36% and 24%, respectively. Mortality during ICU stay was 24%. The length of hospital stay before ICU admission, shock, vasopressors, mechanical ventilation, abdominal sepsis, Glasgow score and plasmapheresis were all factors associated with mortality. Two new clinical clusters variables (NCVs) were defined: Time ICU and ICU Support Profile, which were associated with survivor and no survivor variables. Conclusions: Identification of single factors and groups of factors from NCVs will allow implementation of early and aggressive therapies in patients with ADs at the ICU in order to avoid fatal outcomes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1136/lupus-2015-000122
dc.identifier.issn2053-8790
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19220
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleLupus Science and Medicine
dc.relation.citationVolumeVol. 2
dc.relation.ispartofLupus Science and Medicine, ISSN: 2053-8790 Vol. 2, No. 1 (2015)spa
dc.relation.urihttps://lupus.bmj.com/content/2/1/e000122.full.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectantimalarial agentspa
dc.subjectdisease modifying antirheumatic drugspa
dc.subjecthypertensive factorspa
dc.subjectimmunoglobulin Gspa
dc.subjectimmunosuppressive agentspa
dc.subjectsteroidspa
dc.subjecttumor necrosis factorspa
dc.subject.ddcEnfermedadesspa
dc.subject.lembEnfermedades autoinmunesspa
dc.subject.lembCuidados intensivosspa
dc.titleOutcome of patients with autoimmune diseases in the intensive care unit : A mixed cluster analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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