Ítem
Solo Metadatos

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

dc.creatorLiu, Kespa
dc.creatorKurien, Biji Tspa
dc.creatorZimmerman, Sarah Lspa
dc.creatorKaufman, Kenneth Mspa
dc.creatorTaft, Diana Hspa
dc.creatorKottyan, Leah Cspa
dc.creatorLazaro, Saraspa
dc.creatorWeaver, Carrie Aspa
dc.creatorIce, John Aspa
dc.creatorAdler, Adam Jspa
dc.creatorChodosh, Jamesspa
dc.creatorRadfar, Lidaspa
dc.creatorRasmussen, Astridspa
dc.creatorStone, Donald Uspa
dc.creatorLewis, David Mspa
dc.creatorLi, Shibospa
dc.creatorKoelsch, Kristi Aspa
dc.creatorIgoe, Annspa
dc.creatorTalsania, Mitalispa
dc.creatorKumar, Jayspa
dc.creatorMaier-Moore, Jacen Sspa
dc.creatorHarris, Valerie Mspa
dc.creatorGopalakrishnan, Rajaramspa
dc.creatorJonsson, Rolandspa
dc.creatorLessard, James Aspa
dc.creatorLu, Xianglanspa
dc.creatorGottenberg, Jacques-Ericspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorCunninghame-Graham, Deborah Sspa
dc.creatorHuang, Andrew J Wspa
dc.creatorBrennan, Michael Tspa
dc.creatorHughes, Pamelaspa
dc.creatorIllei, Gabor Gspa
dc.creatorMiceli-Richard, Corinnespa
dc.creatorKeystone, Edward Cspa
dc.creatorBykerk, Vivian Pspa
dc.creatorHirschfield, Gideonspa
dc.creatorXie, Gangspa
dc.creatorNg, Wan-Faispa
dc.creatorNordmark, Gunnelspa
dc.creatorEriksson, Perspa
dc.creatorOmdal, Roaldspa
dc.creatorRhodus, Nelson Lspa
dc.creatorRischmueller, Maureenspa
dc.creatorRohrer, Michaelspa
dc.creatorSegal, Barbara Mspa
dc.creatorVyse, Timothy Jspa
dc.creatorWahren-Herlenius, Mariespa
dc.creatorWitte, Torstenspa
dc.creatorPons-Estel, Bernardospa
dc.creatorAlarcon-Riquelme, Marta Espa
dc.creatorGuthridge, Joel Mspa
dc.creatorJames, Judith Aspa
dc.creatorLessard, Christopher Jspa
dc.creatorKelly, Jennifer Aspa
dc.creatorThompson, Susan Dspa
dc.creatorGaffney, Patrick Mspa
dc.creatorMontgomery, Courtney Gspa
dc.creatorEdberg, Jeffrey Cspa
dc.creatorKimberly, Robert Pspa
dc.creatorAlarcón, Graciela Sspa
dc.creatorLangefeld, Carl Lspa
dc.creatorGilkeson, Gary Sspa
dc.creatorKamen, Diane Lspa
dc.creatorTsao, Betty Pspa
dc.creatorMcCune, W Josephspa
dc.creatorSalmon, Jane Espa
dc.creatorMerrill, Joan Tspa
dc.creatorWeisman, Michael Hspa
dc.creatorWallace, Daniel Jspa
dc.creatorUtset, Tammy Ospa
dc.creatorBottinger, Erwin Pspa
dc.creatorAmos, Christopher Ispa
dc.creatorSiminovitch, Katherine Aspa
dc.creatorMariette, Xavierspa
dc.creatorSivils, Kathy Lspa
dc.creatorHarley, John Bspa
dc.creatorScofield, R Halspa
dc.date.accessioned2020-05-25T23:59:19Z
dc.date.available2020-05-25T23:59:19Z
dc.date.created2016spa
dc.description.abstractObjective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ?1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls. Methods All subjects in this study were female. We identified subjects with 47,XXX using aggregate data from single-nucleotide polymorphism arrays, and, when possible, we confirmed the presence of 47,XXX using fluorescence in situ hybridization or quantitative polymerase chain reaction. Results We found 47,XXX in 7 of 2,826 SLE patients and in 3 of 1,033 SS patients, but in only 2 of 7,074 controls (odds ratio in the SLE and primary SS groups 8.78 [95% confidence interval 1.67-86.79], P = 0.003 and odds ratio 10.29 [95% confidence interval 1.18-123.47], P = 0.02, respectively). One in 404 women with SLE and 1 in 344 women with SS had 47,XXX. There was an excess of 47,XXX among SLE and SS patients. Conclusion The estimated prevalence of SLE and SS in women with 47,XXX was ?2.5 and ?2.9 times higher, respectively, than that in women with 46,XX and ?25 and ?41 times higher, respectively, than that in men with 46,XY. No statistically significant increase of 47,XXX was observed in other female-biased diseases (primary biliary cirrhosis or RA), supporting the idea of multiple pathways to sex bias in autoimmunity. © 2016, American College of Rheumatology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/art.39560
dc.identifier.issn23265205
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23022
dc.language.isoengspa
dc.publisherJohn Wiley and Sons Inc.spa
dc.relation.citationEndPage1300
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage1290
dc.relation.citationTitleArthritis and Rheumatology
dc.relation.citationVolumeVol. 68
dc.relation.ispartofArthritis and Rheumatology, ISSN:23265205, Vol.68, No.5 (2016); pp. 1290-1300spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84964626469&doi=10.1002%2fart.39560&partnerID=40&md5=66a0683eb69078892705bff17480a215spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordArticlespa
dc.subject.keywordRheumatoideng
dc.subject.keywordSystemiceng
dc.subject.keywordRheumatoideng
dc.subject.keywordFluorescenceeng
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordHumaneng
dc.subject.keywordBiliaryeng
dc.subject.keywordBiliaryeng
dc.subject.keywordXXXeng
dc.subject.keywordSystemiceng
dc.subject.keywordControlled studyspa
dc.subject.keywordXeng
dc.subject.keywordFemalespa
dc.subject.keywordFluorescence in situ hybridizationspa
dc.subject.keywordGene dosagespa
dc.subject.keywordHumanspa
dc.subject.keywordKaryotype 47eng
dc.subject.keywordLive birthspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPrevalencespa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordQuality controlspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSarcoidosisspa
dc.subject.keywordSexspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordX chromosomespa
dc.subject.keywordArthritiseng
dc.subject.keywordAutoimmune Diseasesspa
dc.subject.keywordCase control studyspa
dc.subject.keywordLiver Cirrhosiseng
dc.subject.keywordLupus Erythematosuseng
dc.subject.keywordSarcoidosisspa
dc.subject.keywordSex chromosome aberrationspa
dc.subject.keywordSex Chromosome Disorders of Sex Developmentspa
dc.subject.keywordSex ratiospa
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordTrisomyspa
dc.subject.keywordX chromosomespa
dc.subject.keywordArthritiseng
dc.subject.keywordAutoimmune Diseasesspa
dc.subject.keywordCase-Control Studiesspa
dc.subject.keywordChromosomeseng
dc.subject.keywordFemalespa
dc.subject.keywordGene Dosagespa
dc.subject.keywordHumansspa
dc.subject.keywordIn Situ Hybridizationeng
dc.subject.keywordLiver Cirrhosiseng
dc.subject.keywordLupus Erythematosuseng
dc.subject.keywordPrevalencespa
dc.subject.keywordSarcoidosisspa
dc.subject.keywordSex Chromosome Aberrationsspa
dc.subject.keywordSex Chromosome Disorders of Sex Developmentspa
dc.subject.keywordSex Distributionspa
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordTrisomyspa
dc.titleX Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones