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New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis

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dc.creatorPfaff, Alexander W.spa
dc.creatorde-la-Torre, Alejandraspa
dc.creatorRochet, Elisespa
dc.creatorBrunet, Juliespa
dc.creatorSabou, Marcelaspa
dc.creatorSauer, Arnaudspa
dc.creatorBourcier, Tristanspa
dc.creatorGomez-Marin, Jorge E.spa
dc.creatorCandolfi, Ermannospa
dc.date.accessioned2020-05-26T00:11:46Z
dc.date.available2020-05-26T00:11:46Z
dc.date.created2014spa
dc.description.abstractRetinal lesions or other ocular manifestations are serious consequences of infection with the protozoan parasite Toxoplasma gondii. Whilst classically considered a consequence of congenital transmission, recent screening studies estimated that 2% of T. gondii seropositive persons in Europe and North America have retinal lesions, most of them persisting unnoticed. The situation is more dramatic in South America, probably due to the predominance of virulent strains. Some of these strains seem to exhibit ocular or neuronal tropism and are responsible for severe ocular lesions. Despite the medical importance, the physiopathological mechanisms have only recently begun to be elucidated. The particular immune-privileged situation in the eye has to be considered. Studies on French patients showed low or undetectable ocular parasite loads, but a clear Th1/Th17 type immune reaction. Suitable mouse models have appeared in the last few years. Using such a model, IL-17A proved to impair parasite control and induce pathology. In contrast, in South American patients, the parasite seems to be much less efficiently controlled through a Th2 type or suppressive immune response that favors parasite replication. Finally, several host genetic markers controlling immune response factors have been associated with ocular involvement of T. gondii infection, mainly in South America. © 2013 Australian Society for Parasitology Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ijpara.2013.09.007
dc.identifier.issn207519
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24331
dc.language.isoengspa
dc.relation.citationEndPage107
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage99
dc.relation.citationTitleInternational Journal for Parasitology
dc.relation.citationVolumeVol. 44
dc.relation.ispartofInternational Journal for Parasitology, ISSN:207519, Vol.44, No.2 (2014); pp. 99-107spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84892499165&doi=10.1016%2fj.ijpara.2013.09.007&partnerID=40&md5=decb55eb699face4834934e1aa1c3b82spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDiseasespa
dc.subject.keywordGenespa
dc.subject.keywordGenetic markerspa
dc.subject.keywordParasitespa
dc.subject.keywordParasite transmissionspa
dc.subject.keywordProteinspa
dc.subject.keywordProtozoanspa
dc.subject.keywordVirulencespa
dc.subject.keywordEuropespa
dc.subject.keywordGenetic markerspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGeographic distributionspa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordHost susceptibilityspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunogeneticsspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNorth americaspa
dc.subject.keywordParasite incidencespa
dc.subject.keywordParasite loadspa
dc.subject.keywordParasite prevalencespa
dc.subject.keywordParasite virulencespa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordReviewspa
dc.subject.keywordSouth americaspa
dc.subject.keywordToxoplasmosisspa
dc.subject.keywordSouth americaspa
dc.subject.keywordProtozoaspa
dc.subject.keywordToxoplasma gondiispa
dc.subject.keywordHuman studiesspa
dc.subject.keywordInflammationspa
dc.subject.keywordMouse modelsspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordParasite strainsspa
dc.subject.keywordSouth americaspa
dc.subject.keywordToxoplasma gondiispa
dc.subject.keywordAmericasspa
dc.subject.keywordAnimalsspa
dc.subject.keywordEuropespa
dc.subject.keywordEye diseasesspa
dc.subject.keywordHumansspa
dc.subject.keywordToxoplasmosisspa
dc.subject.keywordHuman studiesspa
dc.subject.keywordInflammationspa
dc.subject.keywordMouse modelsspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordParasite strainsspa
dc.subject.keywordSouth americaspa
dc.subject.keywordToxoplasma gondiispa
dc.titleNew clinical and experimental insights into Old World and neotropical ocular toxoplasmosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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