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Immunogenicity and protection-inducing ability of recombinant Plasmodium vivax rhoptry-associated protein 2 in Aotus monkeys: A potential vaccine candidate

dc.creatorRojas-Caraballo, Josespa
dc.creatorMongui, Alvarospa
dc.creatorGiraldo, Manuel A.spa
dc.creatorDelgado, Gabrielaspa
dc.creatorGranados, Dianaspa
dc.creatorMillan-Cortes, Dianaspa
dc.creatorMartinez, Paolaspa
dc.creatorRodriguez, Raulspa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:02:07Z
dc.date.available2020-05-26T00:02:07Z
dc.date.created2009spa
dc.description.abstractRhoptry proteins have been extensively shown to be important in invasion and parasitophorous vacuole (PV) formation. This work evaluates the immunogenicity and protective efficacy of Plasmodium vivax RAP2 in the non-human Aotus primate model, when expressed as a recombinant molecule in E. coli and formulated in Freund and Alum hydroxide adjuvants. Our results show that rPvRAP2 is immunogenic in both formulations, finding a trend of higher cytokine levels in immunized monkeys, specially in IL-4 levels (using Freund's adjuvant) and IL-5 (using Alum hydroxide). RAP2 is suggested as a P. vivax-vaccine candidate since immunized monkeys exhibited lower parasitemias than control groups after being experimentally challenged with the P. vivax VCG-I strain. © 2009 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2009.02.083
dc.identifier.issn0264410X
dc.identifier.issn13588745
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23450
dc.language.isoengspa
dc.relation.citationEndPage2876
dc.relation.citationIssueNo. 21
dc.relation.citationStartPage2870
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 27
dc.relation.ispartofVaccine, ISSN:0264410X, 13588745, Vol.27, No.21 (2009); pp. 2870-2876spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-64449088031&doi=10.1016%2fj.vaccine.2009.02.083&partnerID=40&md5=b9f51df638ac77777d83049a0da4c0e4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAlum hydroxidespa
dc.subject.keywordAntibodyspa
dc.subject.keywordClindamycinspa
dc.subject.keywordCytokinespa
dc.subject.keywordFreund adjuvantspa
dc.subject.keywordGamma interferonspa
dc.subject.keywordImmunological adjuvantspa
dc.subject.keywordInterleukin 2spa
dc.subject.keywordInterleukin 4spa
dc.subject.keywordInterleukin 5spa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordPrimaquinespa
dc.subject.keywordPyrimethaminespa
dc.subject.keywordQuinine sulfatespa
dc.subject.keywordRecombinant protein pvrap2 vaccinespa
dc.subject.keywordRecombinant rhoptry associated protein 2 vaccinespa
dc.subject.keywordSulfadoxinespa
dc.subject.keywordTumor necrosis factorspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAntibody responsespa
dc.subject.keywordAntibody specificityspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordAotus nancymaaespa
dc.subject.keywordArticlespa
dc.subject.keywordCell vacuolespa
dc.subject.keywordCellular immunityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCytokine productionspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordEscherichia colispa
dc.subject.keywordHumoral immunityspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunizationspa
dc.subject.keywordImmunofluorescencespa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordMonkeyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtectionspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordWestern blottingspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAotidaespa
dc.subject.keywordDisease modelseng
dc.subject.keywordImmunogenetic processesspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordImmune responsespa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordRhoptry-associated proteinspa
dc.subject.keywordVaccine candidatespa
dc.titleImmunogenicity and protection-inducing ability of recombinant Plasmodium vivax rhoptry-associated protein 2 in Aotus monkeys: A potential vaccine candidatespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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