Ítem
Solo Metadatos
Towards a poly-functional synthetic-antimalarial vaccine: Incorporating non-natural elements into artificially-made peptides for mimicking functional pathogen ligand structures representing new site-directed vaccine components
Título de la revista
Autores
Lozano J.M.
Patarroyo M.E.
Fecha
2013
Directores
ISSN de la revista
Título del volumen
Editor
Bentham Science Publishers B.V.
Citations
Métricas alternativas
Resumen
Abstract
The molecular basis for obtaining novel anti-malarial vaccine candidates depends on a considered selection of antigenic peptides, mainly derived from Plasmodium antigens' non-polymorphic regions. Since such targeted-molecules are poorly immunogenic when tested as vaccine components, they usually have to be modified to overcome their immunological phenotype. Transition state theory, explaining how peptidases catalyse a given peptide bond breakage, thus led to reduced amide pseudopeptides being proposed as possible mimetics for a transition-state. Stabilising such high-energy molecular stages could become a strategy for inducing antibodies potentially harbouring catalytic properties. Hence, isostere-bond peptido-mimetics represented a rational choice as potential abzyme-inducers and site-directed designed reduced amide pseudopeptides for obtaining peptide-analogues from selected malarial high-binding motifs. This novel family of vaccine candidates has proved to be an efficient functional antibody-inducer, the latter acting as efficient blockers of Plasmodium infection of human and mouse RBCs. © 2013 Bentham Science Publishers.
Palabras clave
Keywords
Amide pseudopeptide , Epitope , Malaria vaccine , Merozoite surface protein 2 , Parasite antibody , Peptide vaccine , Peptidomimetic agent , Pseudopeptide , Synthetic peptide , Unclassified drug , Antimalarial activity , Article , Erythrocyte , Human , Immune response , Immunogenicity , Immunoprophylaxis , In vitro study , Malaria , Malaria falciparum , Nonhuman , Parasitemia , Passive immunization , Phase transition , Plasmodium (life cycle stage) , Plasmodium falciparum , Priority journal , Protein binding , Protein hydrolysis , Protein motif , Protein targeting , Public health problem , Rodent malaria , Vaccine production , Antimalarial vaccine , Catalytic antibody , Passive immunisation , Peptide-bond isostere , Peptido-mimetic , Pseudopeptide
