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Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

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dc.creatorMaiti, Amit K.spa
dc.creatorKim-Howard, Xanaspa
dc.creatorViswanathan, Parvathispa
dc.creatorGuillén, Lauraspa
dc.creatorQian, Xiaoxiaspa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorSun, Celispa
dc.creatorCañas, Carlosspa
dc.creatorTobón, Gabriel J.spa
dc.creatorMatsuda, Koichispa
dc.creatorShen, Nanspa
dc.creatorCherñavsky, Alejandra C.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorNath, Swapan K.spa
dc.date.accessioned2020-05-26T00:00:37Z
dc.date.available2020-05-26T00:00:37Z
dc.date.created2010spa
dc.description.abstractObjectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using ?2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/rheumatology/kep470
dc.identifier.issn14620324
dc.identifier.issn14620332
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23249
dc.language.isoengspa
dc.relation.citationEndPage1244
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1239
dc.relation.citationTitleRheumatology
dc.relation.citationVolumeVol. 49
dc.relation.ispartofRheumatology, ISSN:14620324, 14620332, Vol.49, No.7 (2010); pp. 1239-1244spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77954208061&doi=10.1093%2frheumatology%2fkep470&partnerID=40&md5=5cd799a98204949dfedaeedbc289287dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCd226 proteinspa
dc.subject.keywordChromosome proteinspa
dc.subject.keyworddifferentiationeng
dc.subject.keywordUnclassified drugspa
dc.subject.keywordt-lymphocyteeng
dc.subject.keywordArgentinaspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCaucasianspa
dc.subject.keywordCeliac diseasespa
dc.subject.keywordChinaspa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordEthnic differencespa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordGeographic distributionspa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordJapanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPhenotypespa
dc.subject.keywordPopulation researchspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAntigenseng
dc.subject.keywordArgentinaspa
dc.subject.keywordAsian continental ancestry groupspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordEuropean continental ancestry groupspa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordStatistics as topicspa
dc.subject.keywordAsiaspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCd226spa
dc.subject.keywordLatin-americaspa
dc.titleNon-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseasesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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