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Persistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women : A follow-up study

dc.creatorSoto De León, Sara Cecilia
dc.creatorDel Río-Ospina, Luisa
dc.creatorCamargo, Milena
dc.creatorSánchez, Ricardo
dc.creatorMoreno‑Pérez, Darwin A.
dc.creatorPérez Prados, Antonio
dc.creatorPatarroyo, Manuel-Elkin
dc.creatorPatarroyo, Manuel A.
dc.creator.googleSoto-De León, Sara Cspa
dc.creator.googleDel Río-Ospina, Luisaspa
dc.creator.googleCamargo, Milenaspa
dc.creator.googleSánchez, Ricardospa
dc.creator.googleMoreno-Pérez, Darwin Aspa
dc.creator.googlePérez-Prados, Antoniospa
dc.creator.googlePatarroyo, Manuel Espa
dc.creator.googlePatarroyo, Manuel Aspa
dc.date.accessioned2020-04-23T14:55:43Z
dc.date.available2020-04-23T14:55:43Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractBackground: The design of new healthcare schemes which involve using molecular HPV screening means that both persistence and clearance data regarding the most prevalent types of HR-HPV occurring in cities in Colombia must be ascertained.Methods: This study involved 219 HPV positive women in all of whom 6 types of HR-HPV had been molecularly identified and quantified; they were followed-up for 2 years. The Kaplan-Meier survival function was used for calculating the time taken for the clearance of each type of HPV. The role of a group of independent variables concerning the time taken until clearance was evaluated using a Cox proportional-hazards regression model or parametric (log-logistic) methods when necessary. Regarding viral load, the Wilcoxon rank-sum test was used for measuring the difference of medians for viral load for each type, according to the state of infection (cleared or persistent). The Kruskal-Wallis test was used for evaluating the change in the women's colposcopy findings at the start of follow-up and at the end of it (whether due to clearance or the end of the follow-up period).Results: It was found that HPV-18 and HPV-31 types had the lowest probability of becoming cleared (1.76 and 2.75 per 100 patients/month rate, respectively). Women from Colombian cities other than Bogotá had a greater probability of being cleared if they had HPV-16 (HR 2.58: 1.51-4.4 95% CI) or HPV-58 (1.79 time ratio: 1.33-2.39 95% CI) infection. Regarding viral load, HPV-45-infected women having 1 × 106 to 9.99 × 109 viral copies had better clearance compared to those having greater viral loads (1.61 time ratio: 1.01-2.57 95% CI). Lower HPV-31 viral load values were associated with this type's persistence and changes in colposcopy findings for HPV-16 gave the worst prognosis in women having low absolute load values.Conclusions: HPV infection clearance in this study was related to factors such as infection type, viral load and the characteristics of the cities from which the women came. Low viral load values would indicate viral persistence and a worse prognosis regarding a change in colposcopy findings. © 2014 Soto-De León et al.; licensee BioMed Central Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/1471-2334-14-395
dc.identifier.issn1471-2334
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21746
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleBMC Infectious Diseases
dc.relation.citationVolumeVol. 14
dc.relation.ispartofBMC Infectious Diseases, ISSN: 1471-2334 Vol. 14, No. 1 (2014)spa
dc.relation.urihttps://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/1471-2334-14-395spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectColombiaspa
dc.subjectPersistenciaspa
dc.subjectEstudio de seguimientospa
dc.subject.ddcIncidencia & prevención de la enfermedadspa
dc.subject.keywordHR-HPVspa
dc.subject.keywordPersistencespa
dc.subject.keywordClearance timespa
dc.subject.keywordColombiaspa
dc.subject.keywordFollow-up studyspa
dc.subject.lembEpidemiologíaspa
dc.subject.lembPapilomaspa
dc.subject.lembEstudiospa
dc.titlePersistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women : A follow-up studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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