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Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose

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dc.creatorMelo O.L.spa
dc.creatorNogué S.spa
dc.creatorTrullás J.C.spa
dc.creatorAguiló S.spa
dc.creatorMaciel A.spa
dc.date.accessioned2020-05-26T00:00:08Z
dc.date.available2020-05-26T00:00:08Z
dc.date.created2004spa
dc.description.abstractFlumazenil is a competitive inhibitor of the GABA receptor which effectively counteracts the effects of benzodiazepine overdose. It is considered to be safe, although infrequent adverse effects, including seizures, have been described. We present the case of a 30-year-old patient who was found in coma after taking an unknown amount of benzodiazepines and tricyclic antidepressants in an attempt to commit suicide After the administration of flumazenil, the patient suffered generalized tonic-clonic seizure. The patient was admitted to the ICU due to respiratory insufficiency secondary to broncoaspiration, with a satisfactory evolution after 48 hours. The risk factors for the development of seizure after flumazenil admisnistracion are discussed, recomendation for its safe use are suggested.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn16970748
dc.identifier.issn02127113
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23167
dc.language.isoengspa
dc.relation.citationEndPage40
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage38
dc.relation.citationTitleRevista de Toxicologia
dc.relation.citationVolumeVol. 21
dc.relation.ispartofRevista de Toxicologia, ISSN:16970748, 02127113, Vol.21, No.1 (2004); pp. 38-40spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-2542566638&partnerID=40&md5=d09a5dbef0e52934951e8e3f3a05bd48spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBenzodiazepinespa
dc.subject.keywordFlumazenilspa
dc.subject.keywordTricyclic antidepressant agentspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordCase reportspa
dc.subject.keywordClinical featurespa
dc.subject.keywordComaspa
dc.subject.keywordDisease coursespa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordIntensive carespa
dc.subject.keywordRespiratory failurespa
dc.subject.keywordRisk factorspa
dc.subject.keywordSuicide attemptspa
dc.subject.keywordTonic clonic seizurespa
dc.subject.keywordBenzodiazepinesspa
dc.subject.keywordComaspa
dc.subject.keywordFlumazenilspa
dc.subject.keywordSeizuresspa
dc.subject.keywordTricyclic antidepressantspa
dc.titleSeizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdosespa
dc.title.TranslatedTitleConvulsiones secundarias a la administracion de flumazenilo en un caso de sobredosis de benzodiacepinas y antidepresivos tricíclicosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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