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Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin

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dc.creatorde-la-Torre, Alejandraspa
dc.creatorValdés-Camacho, Juanitaspa
dc.creatorde Mesa, Clara Lópezspa
dc.creatorUauy-Nazal, Andrésspa
dc.creatorZuluaga, Juan Davidspa
dc.creatorRamírez-Páez, Lina Maríaspa
dc.creatorDurán, Felipespa
dc.creatorTorres-Morales, Elizabethspa
dc.creatorTriviño, Jessicaspa
dc.creatorMurillo, Mateospa
dc.creatorPeñaranda, Alba Cristinaspa
dc.creatorSepúlveda-Arias, Juan Carlosspa
dc.creatorGómez-Marín, Jorge Enriquespa
dc.date.accessioned2020-05-26T00:03:09Z
dc.date.available2020-05-26T00:03:09Z
dc.date.created2019spa
dc.description.abstractBackground: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools. Methods: Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016. Aqueous humor (AH) and/or vitreous fluid, blood and serum samples were collected from consecutive patients suspected of having infectious uveitis. The diagnosis of ocular toxoplasmosis (OT) was confirmed by the Goldmann-Witmer coefficient (GWC) and by polymerase chain reaction (PCR). Differential diagnosis by PCR in AH was done for viral origin such as Cytomegalovirus (CMV), Herpes simplex virus type 1 (HSV1), Herpes simplex virus type 2 (HSV2), Varicella zoster virus (VZV), Epstein-Barr virus (EBV) and Mycobacterium tuberculosis. Results: In 66 Colombian patients with uveitis of presumed infectious origin: 22 (33.3%) were confirmed as OT, 16 (24.2%) as undetermined OT, five (7.5%) as co-infections and 23 (34.8%) as other uveitis. Toxoplasma coinfection with M. tuberculosis was identified in one case by PCR and in four cases with HSV by GWC. The initial clinical diagnosis changed, after laboratory examination, in 21 cases (31.8%). Conclusions: Clinical diagnosis can be changed by laboratory examination in a significant proportion of cases of uveitis. Diagnosis of OT should combine the use of PCR and GWC to reach the maximum of confirmation of cases. The use of multiple laboratory methods is necessary to identify co-infections and viral infections that can mimic OT in immunocompetent patients. © 2019 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12879-018-3613-8
dc.identifier.issn14712334
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23566
dc.language.isoengspa
dc.publisherBioMed Central Ltd.spa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleBMC Infectious Diseases
dc.relation.citationVolumeVol. 19
dc.relation.ispartofBMC Infectious Diseases, ISSN:14712334, Vol.19, No.1 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060537408&doi=10.1186%2fs12879-018-3613-8&partnerID=40&md5=db6d57e7b3f2119216eba00708eb54dbspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntiinflammatory agentspa
dc.subject.keywordviraleng
dc.subject.keywordAntiparasitic agentspa
dc.subject.keyworddifferentialeng
dc.subject.keywordparasiticeng
dc.subject.keywordviraleng
dc.subject.keywordAntiretrovirus agentspa
dc.subject.keywordImmunomodulating agentspa
dc.subject.keywordTuberculostatic agentspa
dc.subject.keywordValganciclovirspa
dc.subject.keywordVirus dnaspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAqueous humorspa
dc.subject.keywordArticlespa
dc.subject.keywordBlood samplingspa
dc.subject.keywordClinical examinationspa
dc.subject.keywordColombiaspa
dc.subject.keywordColombianspa
dc.subject.keywordCytomegalovirus infectionspa
dc.subject.keywordDescriptive researchspa
dc.subject.keywordDiagnostic testspa
dc.subject.keywordDifferential diagnosisspa
dc.subject.keywordDrug substitutionspa
dc.subject.keywordDrug withdrawalspa
dc.subject.keywordEpstein barr virus infectionspa
dc.subject.keywordFemalespa
dc.subject.keywordGoldmann witmer coefficientspa
dc.subject.keywordHerpes simplex virus 2spa
dc.subject.keywordHerpes zosterspa
dc.subject.keywordHerpes zoster ophthalmicusspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman alphaherpesvirus 1spa
dc.subject.keywordImmunocompetencespa
dc.subject.keywordLaboratory testspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMixed infectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordOcular tuberculosisspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordSerumspa
dc.subject.keywordUveitisspa
dc.subject.keywordVitreous bodyspa
dc.subject.keywordComplicationspa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordDifferential diagnosisspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHerpes virus infectionspa
dc.subject.keywordImmunocompetencespa
dc.subject.keywordImmunologyspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMixed infectionspa
dc.subject.keywordParasitic eye infectionspa
dc.subject.keywordToxoplasmosisspa
dc.subject.keywordViral eye infectionspa
dc.subject.keywordVirologyspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordColombiaspa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordDiagnosiseng
dc.subject.keywordDnaeng
dc.subject.keywordEye infectionseng
dc.subject.keywordEye infectionseng
dc.subject.keywordFemalespa
dc.subject.keywordHerpesviridae infectionsspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunocompetencespa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordToxoplasmosisspa
dc.subject.keywordYoung adultspa
dc.subject.keywordCo-infectionsspa
dc.subject.keywordDiagnosisspa
dc.subject.keywordGoldmann-witmerspa
dc.subject.keywordImmunocompetentspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordPcrspa
dc.titleCoinfections and differential diagnosis in immunocompetent patients with uveitis of infectious originspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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