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Untangling the transmission dynamics of primary and secondary vectors of Trypanosoma cruzi in Colombia : Parasite infection, feeding sources and discrete typing units

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dc.creatorHernández, Carolina
dc.creatorSalazar, Camilo
dc.creatorBrochero, Helena
dc.creatorTeherán, Aníbal
dc.creatorBuitrago, Luz Stella
dc.creatorVera, Mauricio
dc.creatorSoto, Hugo
dc.creatorFlorez-Rivadeneira, Zulibeth
dc.creatorArdila, Sussane
dc.creatorParra-Henao, Gabriel
dc.creatorRamírez, Juan David
dc.creator.googleHernández, Carolinaspa
dc.creator.googleSalazar, Camilospa
dc.creator.googleBrochero, Helenaspa
dc.creator.googleTeherán, Anibalspa
dc.creator.googleBuitrago, Luz Stellaspa
dc.creator.googleVera, Mauriciospa
dc.creator.googleSoto, Hugospa
dc.creator.googleFlorez-Rivadeneira, Zulibethspa
dc.creator.googleArdila, Sussanespa
dc.creator.googleParra-Henao, Gabrielspa
dc.creator.googleRamírez, Juan Davidspa
dc.date.accessioned2020-04-01T16:39:25Z
dc.date.available2020-04-01T16:39:25Z
dc.date.created2016
dc.date.issued2016
dc.description.abstractBackground: Trypanosoma cruzi is the causative agent of Chagas disease. Due to its genetic diversity has been classified into six Discrete Typing Units (DTUs) in association with transmission cycles. In Colombia, natural T. cruzi infection has been detected in 15 triatomine species. There is scarce information regarding the infection rates, DTUs and feeding preferences of secondary vectors. Therefore, the aim of this study was to determine T. cruzi infection rates, parasite DTU, ecotopes, insect stages, geographical location and bug feeding preferences across six different triatomine species. Methods: A total of 245 insects were collected in seven departments of Colombia. We conducted molecular detection and genotyping of T. cruzi with subsequent identification of food sources. The frequency of infection, DTUs, TcI genotypes and feeding sources were plotted across the six species studied. A logistic regression model risk was estimated with insects positive for T. cruzi according to demographic and eco-epidemiological characteristics. Results: We collected 85 specimens of Panstrongylus geniculatus, 77 Rhodnius prolixus, 37 R. pallescens, 34 Triatoma maculata, 8 R. pictipes and 4 T. dimidiata. The overall T. cruzi infection rate was 61.2% and presented statistical associations with the departments Meta (OR: 2.65; 95% CI: 1.69-4.17) and Guajira (OR: 2.13; 95% CI: 1.16-3.94); peridomestic ecotope (OR: 2.52: 95% CI: 1.62-3.93); the vector species P. geniculatus (OR: 2.40; 95% CI: 1.51-3.82) and T. maculata (OR: 2.09; 95% CI: 1.02-4.29); females (OR: 2.05; 95% CI: 1.39-3.04) and feeding on opossum (OR: 3.15; 95% CI: 1.85-11.69) and human blood (OR: 1.55; 95% CI: 1.07-2.24). Regarding the DTUs, we observed TcI (67.3%), TcII (6.7%), TcIII (8.7%), TcIV (4.0%) and TcV (6.0%). Across the samples typed as TcI, we detected TcIDom (19%) and sylvatic TcI (75%). The frequencies of feeding sources were 59.4% (human blood); 11.2% (hen); 9.6% (bat); 5.6% (opossum); 5.1% (mouse); 4.1% (dog); 3.0% (rodent); 1.0% (armadillo); and 1.0% (cow). Conclusions: New scenarios of T. cruzi transmission caused by secondary and sylvatic vectors are considered. The findings of sylvatic DTUs from bugs collected in domestic and peridomestic ecotopes confirms the emerging transmission scenarios in Colombia. © 2016 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s13071-016-1907-5
dc.identifier.issn1756-3305
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21357
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleParasites and Vectors
dc.relation.citationVolumeVol. 9
dc.relation.ispartofParasites and Vectors, ISSN: 1756-3305 Vol. 9, No. 1 (2016)spa
dc.relation.urihttps://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/s13071-016-1907-5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectEnfermedad de Chagasspa
dc.subjectVectores secundariosspa
dc.subjectTrypanosoma cruzispa
dc.subjectDTUspa
dc.subjectFuentes de alimentaciónspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordSecondary vectorsspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordDTUsspa
dc.subject.keywordFeeding sourcesspa
dc.subject.lembTrypanosoma cruzispa
dc.subject.lembEnfermedad de chagasspa
dc.subject.lembInfecciones por protozoariosspa
dc.titleUntangling the transmission dynamics of primary and secondary vectors of Trypanosoma cruzi in Colombia : Parasite infection, feeding sources and discrete typing unitsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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