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Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease

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dc.creatorZandman?Goddard, Giselespa
dc.creatorBerkun, Yackovspa
dc.creatorBarzilai, Orispa
dc.creatorBoaz, Monaspa
dc.creatorBlank, Mirispa
dc.creatorRam, Mayaspa
dc.creatorSherer, Yanivspa
dc.creatorAnaya, Juan-Manuel
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-25T23:56:08Z
dc.date.available2020-05-25T23:56:08Z
dc.date.created2009spa
dc.description.abstractInfections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P less than 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P less than 0.005). VCA IgG titers were significantly elevated (P less than 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs. © 2009 New York Academy of Sciences.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1749-6632.2009.04754.x
dc.identifier.issn778923
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22333
dc.language.isoengspa
dc.publisherBlackwell Publishing Inc.spa
dc.relation.citationEndPage663
dc.relation.citationStartPage658
dc.relation.citationTitleAnnals of the New York Academy of Sciences
dc.relation.citationVolumeVol. 1173
dc.relation.ispartofAnnals of the New York Academy of Sciences, ISSN:778923, Vol.1173,(2009); pp. 658-663spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-69949178754&doi=10.1111%2fj.1749-6632.2009.04754.x&partnerID=40&md5=8648a443cd5118241a14c0ae2f9abb8espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCell nucleus antigenspa
dc.subject.keywordEarly antigenspa
dc.subject.keywordHeterophile antibodyspa
dc.subject.keywordHeterophile antigenspa
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordVirus capsid antigenspa
dc.subject.keywordAdultspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordConference paperspa
dc.subject.keywordControl groupspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordDisease severityspa
dc.subject.keywordEpstein barr virusspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordHuman tissuespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPhenotypespa
dc.subject.keywordPredictionspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordVirus capsidspa
dc.subject.keywordVirus infectionspa
dc.subject.keywordHuman herpesvirus 4spa
dc.subject.keywordMiridaespa
dc.subject.keywordAbsspa
dc.subject.keywordEbvspa
dc.subject.keywordLupusspa
dc.subject.keywordMild diseasespa
dc.subject.keywordSlespa
dc.titleExposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus diseasespa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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