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Serotonin transporter gene (5-HTT) polymorphism and major depressive disorder in patients in bogotá, Colombia

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dc.creatorPerez-Olmos, Isabel
dc.creatorBustamante, Deliaspa
dc.creatorIbáñez Pinilla, Milcíadesspa
dc.date.accessioned2020-05-26T00:02:56Z
dc.date.available2020-05-26T00:02:56Z
dc.date.created2016spa
dc.description.abstractIntroduction: The 5-HTT short allele has been controversially associated with an increased risk of major depressive disorder. Objective: To determine the association of 5-HTT short allele with major depression in Bogotá, Colombia. Materials and methods: We carried out a study of cases (n=68) matched 1:1 with controls by gender and age (±5 years). Major depression was diagnosed using the Mini-International Neuropsychiatric Interview, and 5-HTT polymorphism using PCR. Results: Females were predominant (82.4%). The S (short) allele predominated in cases compared with controls (S: 72.1% vs. 63.2; L (long): 27.9% vs. 36.8%), and the SL genotype was more frequent in cases (SL: 45.6% vs. 36.8%; LL: 27.9% vs. 36.8%; SS: 26.5% vs. 26.5%), although not significantly. There were significant differences in those under age 37, with a predominance of the S allele in cases (p=0.038; OR=2.75; 95% CI: 0.88-8.64). Multivariate analysis, adjusted for comorbid anxiety disorders, showed a significant association of major depression with the SL genotype (p=0.049; OR=3.20; 95% CI: 1.00-10.23); the S allele was close to statistical significance (p=0.063; OR=2.94; 95% CI: 0.94-9.13), and it was statistically significant in cases under 37 years of age (p=0.026; OR=10.79; 95% CI: 1.32-80.36). Conclusions: The SL genotype was associated with major depressive disorder in patients of all ages. The S allele was significantly associated with major depressive disorder in patients under age 37, adjusted for comorbid anxiety disorders.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.7705/biomedica.v36i3.3014
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23543
dc.language.isoengspa
dc.publisherInstituto Nacional de Saludspa
dc.relation.citationEndPage294
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage285
dc.relation.citationTitleBiomedica
dc.relation.citationVolumeVol. 36
dc.relation.ispartofBiomedica, Vol.36, No.2 (2016); pp. 285-294spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84980413892&doi=10.7705%2fbiomedica.v36i3.3014&partnerID=40&md5=e383262fb0f75865796fc78de6654a4dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordSerotonin transporterspa
dc.subject.keywordAllelespa
dc.subject.keywordAnxiety disorderspa
dc.subject.keywordColombiaspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor depressionspa
dc.subject.keywordMetabolismspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordAllelesspa
dc.subject.keywordAnxiety disordersspa
dc.subject.keywordColombiaspa
dc.subject.keywordDepressive disordereng
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSerotonin plasma membrane transport proteinsspa
dc.subject.keywordAnxiety disordersspa
dc.subject.keywordComorbidityspa
dc.subject.keywordDepressive disorderspa
dc.subject.keywordGeneticspa
dc.subject.keywordMajorspa
dc.subject.keywordPolymorphismspa
dc.subject.keywordRiskspa
dc.subject.keywordSerotoninspa
dc.subject.keywordSuicidespa
dc.titleSerotonin transporter gene (5-HTT) polymorphism and major depressive disorder in patients in bogotá, Colombiaspa
dc.title.TranslatedTitlePolimorfismo del gen del transportador de serotonina (5-HTT) y trastorno de depresión mayor en pacientes en bogotá, Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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