Ítem
Solo Metadatos

From a basic to a functional approach for developing a blood stage vaccine against Plasmodium vivax

Mostrar el registro sencillo de la publicación
dc.creatorPatarroyo, Manuel A.
dc.creatorArévalo-Pinzón, Gabrielaspa
dc.creatorMoreno-Pérez, Darwin Aspa
dc.date.accessioned2020-05-26T00:08:02Z
dc.date.available2020-05-26T00:08:02Z
dc.date.created2020spa
dc.description.abstractIntroduction: Numerous challenges have hampered developing an anti-malarial vaccine against the most widespread malarial parasite worldwide: Plasmodium vivax. Despite the progress achieved in studying proteins in short-term in vitro culture or in experimental models, there is still no clear method for defining which antigens or their regions should be prioritized for including them in a vaccine. Areas covered: The methods used by research groups so far which have focused on the functional analysis of P. vivax blood stage antigens have been reviewed here. A logical strategy orientated toward resolving two of the most commonly occurring problems in designing vaccines against this species has thus been proposed (i.e. the search for candidates and evaluating/ascertaining their functional role in the invasion of such molecules). Expert commentary: Advances in knowledge regarding P. vivax biology have been extremely slow. Only two key receptor–ligand interactions concerning merozoite entry to reticulocytes have been reported during the last 20 years: PvDBP1-DARC and PvRBP2b-CD71. Despite increasing knowledge about the parasite’s intimate preference for its host cells, it has yet to be determined which regions of the merozoite molecules characterized to date meet the requirement of inducing protective immune responses effectively blocking heterologous parasite entry to human cells. © 2020, © 2020 Informa UK Limited, trading as Taylor and Francis Group.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1080/14760584.2020.1733421
dc.identifier.issn14760584
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24050
dc.language.isoengspa
dc.publisherTaylor and Francis Ltdspa
dc.relation.citationEndPage207
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage195
dc.relation.citationTitleExpert Review of Vaccines
dc.relation.citationVolumeVol. 19
dc.relation.ispartofExpert Review of Vaccines, ISSN:14760584, Vol.19, No.2 (2020); pp. 195-207spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85080136022&doi=10.1080%2f14760584.2020.1733421&partnerID=40&md5=62d006e8d895475d3936104ab684bee4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordEpitopespa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordProtozoal vaccinespa
dc.subject.keywordAntigenicityspa
dc.subject.keywordCell interactionspa
dc.subject.keywordDna polymorphismspa
dc.subject.keywordJk-1 cell linespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPlatyrrhinispa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein functionspa
dc.subject.keywordProtein interactionspa
dc.subject.keywordReticulocytespa
dc.subject.keywordReverse geneticsspa
dc.subject.keywordReviewspa
dc.subject.keywordIn vitro culturespa
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtective immune responsespa
dc.subject.keywordReceptor-ligand interactionspa
dc.subject.keywordVaccinespa
dc.titleFrom a basic to a functional approach for developing a blood stage vaccine against Plasmodium vivaxspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos