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Nonlinear Transfer Entropy to Assess the Neurovascular Coupling in Premature Neonates

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dc.creatorCaicedo Dorado, Alexander
dc.creatorThewissen, Liesbethspa
dc.creatorNaulaers, Gunnarspa
dc.creatorSmits, Annespa
dc.creatorVan Huffel. Sabinespa
dc.creatorAllegaert, Karelspa
dc.date.accessioned2020-08-28T15:50:00Z
dc.date.available2020-08-28T15:50:00Z
dc.date.created2020-01-01spa
dc.description.abstractIn the adult brain, it is well known that increases in local neural activity trigger changes in regional blood flow and, thus, changes in cerebral energy metabolism. This regulation mechanism is called neurovascular coupling (NVC). It is not yet clear to what extent this mechanism is present in the premature brain. In this study, we explore the use of transfer entropy (TE) in order to compute the nonlinear coupling between changes in brain function, assessed by means of EEG, and changes in brain oxygenation, assessed by means of near-infrared spectroscopy (NIRS). In a previous study, we measured the coupling between both variables using a linear model to compute TE. The results indicated that changes in brain oxygenation were likely to precede changes in EEG activity. However, using a nonlinear and nonparametric approach to compute TE, the results indicate an opposite directionality of this coupling. The source of the different results provided by the linear and nonlinear TE is unclear and needs further research. In this study, we present the results from a cohort of 21 premature neonates. Results indicate that TE values computed using the nonlinear approach are able to discriminate between neonates with brain abnormalities and healthy neonates, indicating a less functional NVC in neonates with brain abnormalities. Keywordseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/978-3-030-34461-0_2
dc.identifier.issnISBN: 978-1-4419-7755-7
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28884
dc.language.isoengspa
dc.publisherspringer Naturespa
dc.relation.citationEndPage17
dc.relation.citationStartPage11
dc.relation.citationTitleAdvances in Experimental Medicine and Biology
dc.relation.citationVolumeVol. 1232
dc.relation.ispartofAdvances in Experimental Medicine and Biology, ISBN: 978-1-4419-7755-7, Vol.1232 (2020); pp. 11-17spa
dc.relation.urihttps://link.springer.com/chapter/10.1007/978-3-030-34461-0_2spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceAdvances in Experimental Medicine and Biologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordNeurometabolic Coupling (NMC)spa
dc.subject.keywordTransfer Entropy (TE)spa
dc.subject.keywordEEGspa
dc.subject.keywordNIRSspa
dc.subject.keywordPremature Neonatesspa
dc.titleNonlinear Transfer Entropy to Assess the Neurovascular Coupling in Premature Neonatesspa
dc.title.TranslatedTitleEntropía de transferencia no lineal para evaluar el acoplamiento neurovascular en recién nacidos prematurosspa
dc.typebookParteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaParte de librospa
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