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Mammaglobin peptide as a novel biomarker for breast cancer detection

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dc.creatorGalvis-Jiménez, Julie Mspa
dc.creatorCurtidor, Hernandospa
dc.creatorPatarroyo, Manuel A.
dc.creatorMonterrey, Pedro
dc.creatorRamírez Clavijo, Sandra Rocíospa
dc.date.accessioned2020-05-26T00:03:47Z
dc.date.available2020-05-26T00:03:47Z
dc.date.created2013spa
dc.description.abstractAmong the different types of tests used for cancer diagnosis, molecular tests have been increrasingly incorporated because of their ability to detect either expression or functional changes in the molecules associated with the disease. Mammaglobin is a protein found in mammary tissue and can be detected in serum. This protein has been proposed as a biomarker to diagnose breast cancer, given that patients exhibit an increased amount of the protein in serum and tumor tissue, in comparison to healthy individuals. The ELISA test was used in the present study to detect mammaglobin in blood samples from 51 breast cancer patients and 51 control individuals. Antibodies against mamaglobin were generated in rabbits by using the following synthetic peptides: A (amino acids 13 to 21), B (amino acids 31 to 39), C (amino acids 56 to 64) and a D peptide, corresponding to the protein isoform without three amino acids (59, 60 and 61 amino acids) from peptide C. All peptides were immunogenic and allowed generation of antibodies that were able to discriminate patients from controls. The best results were obtained for antiserum B, achieving the best sensitivity (86.3%) and specificity (96%). © 2012 Landes Bioscience.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4161/cbt.23614
dc.identifier.issn15384047
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23629
dc.language.isoengspa
dc.relation.citationEndPage332
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage327
dc.relation.citationTitleCancer Biology and Therapy
dc.relation.citationVolumeVol. 14
dc.relation.ispartofCancer Biology and Therapy, ISSN:15384047, Vol.14, No.4 (2013); pp. 327-332spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84875867999&doi=10.4161%2fcbt.23614&partnerID=40&md5=7de593be42fca00b0687bde81c84be4bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmino acidspa
dc.subject.keywordbiologicaleng
dc.subject.keywordAntibodyspa
dc.subject.keywordC peptidespa
dc.subject.keywordIsoproteinspa
dc.subject.keywordMammaglobinspa
dc.subject.keywordSynthetic peptidespa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordBlood samplingspa
dc.subject.keywordBreast cancerspa
dc.subject.keywordCancer diagnosisspa
dc.subject.keywordCancer patientspa
dc.subject.keywordControlled studyspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman tissuespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordSensitivity and specificityspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordBreast neoplasmsspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordEnzyme-linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordImmune seraspa
dc.subject.keywordMammaglobin aspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPeptide fragmentsspa
dc.subject.keywordRabbitsspa
dc.subject.keywordTumor markerseng
dc.subject.keywordBiomarkerspa
dc.subject.keywordBreast cancerspa
dc.subject.keywordDiagnosisspa
dc.subject.keywordElisaspa
dc.subject.keywordHuman mammaglobinspa
dc.titleMammaglobin peptide as a novel biomarker for breast cancer detectionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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