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Evaluating Sarconesiopsis magellanica blowfly-derived larval therapy and comparing it to Lucilia sericata-derived therapy in an animal model

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dc.creatorDíaz-Roa, Andreaspa
dc.creatorGaona, María A.spa
dc.creatorSegura, Nidya A.spa
dc.creatorRamírez-Hernández, Alejandrospa
dc.creatorCortés-Vecino, Jesús A.spa
dc.creatorPatarroyo, Manuel A.spa
dc.creatorBello, Feliospa
dc.date.accessioned2020-05-26T00:03:56Z
dc.date.available2020-05-26T00:03:56Z
dc.date.created2016spa
dc.description.abstractLarval therapy is used as alternative treatment for hard-to-heal chronic and infected wounds. Lucilia sericata is the most used blowfly species. However, it has been shown recently that Sarconesiopsis magellanica larval excretions and secretions have potent antibacterial activity; this blowfly belongs to the Calliphoridae family.The present work has dealt with evaluating larval therapy using S. magellanica on wounds induced in diabetic rabbits and its action was compared to the effect induced by L. sericata. Twelve New Zealand White rabbits (. Oryctolagus cuniculus) were used; they were divided into 4 groups, the first two being treated with larval therapy derived from both aforementioned necrophagous blowflies, an antibiotic was used in the third and the fourth was used as control. All the animals were wounded on the back and infected with Pseudomonas aeruginosa and Staphylococcus aureus.Samples of the secretion from each animal's infected wound were taken and sown on blood agar. The colony forming units were then counted. The PUSH scale was used for the macroscopic evaluation of the wounds.Bacterial control was encountered 48. h post-treatment in the treatments involving larval therapy and to a lesser extent with the antibiotic. Likewise, wound debridement was quicker and more efficient with larval therapy compared to the antibiotic group; however, wound closing time was 23 days in all treatments. The group treated with S. magellanica larvae had relatively quicker evolution until the proliferation phase and the start of maturation, even though there were no significant differences between both blowfly species evaluated here regarding treatments by the end of the treatment period.The present study has validated the diabetic rabbit model for inducing chronic wounds regarding larval therapy and has likewise confirmed the effectiveness of S. magellanica-derived larval therapy as an alternative for curing and healing wounds. © 2015 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2015.10.024
dc.identifier.issn0001706X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23641
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage41
dc.relation.citationStartPage34
dc.relation.citationTitleActa Tropica
dc.relation.citationVolumeVol. 154
dc.relation.ispartofActa Tropica, ISSN:0001706X, Vol.154,(2016); pp. 34-41spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84947969716&doi=10.1016%2fj.actatropica.2015.10.024&partnerID=40&md5=7b826057f09a6dc2dd1c68d624c41829spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntibioticsspa
dc.subject.keywordexperimentaleng
dc.subject.keywordDiabetesspa
dc.subject.keywordFlyspa
dc.subject.keywordLagomorphspa
dc.subject.keywordMedicinespa
dc.subject.keywordModelingspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordAntibacterial activityspa
dc.subject.keywordAntibiotic therapyspa
dc.subject.keywordArticlespa
dc.subject.keywordBacterial loadspa
dc.subject.keywordCalliphoridaespa
dc.subject.keywordChronic woundspa
dc.subject.keywordColony forming unitspa
dc.subject.keywordComparative effectivenessspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDebridementspa
dc.subject.keywordDiabetes mellitusspa
dc.subject.keywordIntermethod comparisonspa
dc.subject.keywordLucilia sericataspa
dc.subject.keywordMaggot therapyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordOryctolagus cuniculusspa
dc.subject.keywordPseudomonas infectionspa
dc.subject.keywordSarconesiopsis magellanicaspa
dc.subject.keywordStaphylococcus infectionspa
dc.subject.keywordWound healingspa
dc.subject.keywordWound healing impairmentspa
dc.subject.keywordWound infectionspa
dc.subject.keywordAnimalspa
dc.subject.keywordComparative studyspa
dc.subject.keywordDiabetes mellituseng
dc.subject.keywordDipteraspa
dc.subject.keywordDisease modelspa
dc.subject.keywordLarvaspa
dc.subject.keywordPathologyspa
dc.subject.keywordRabbitspa
dc.subject.keywordWound infectionspa
dc.subject.keywordAnimaliaspa
dc.subject.keywordBacteria (microorganisms)spa
dc.subject.keywordCalliphoridaespa
dc.subject.keywordLucilia sericataspa
dc.subject.keywordOryctolagus cuniculusspa
dc.subject.keywordPseudomonas aeruginosaspa
dc.subject.keywordStaphylococcusspa
dc.subject.keywordAlloxanspa
dc.subject.keywordAntiinfective agentspa
dc.subject.keywordAlloxanspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAnti-bacterial agentsspa
dc.subject.keywordDiabetes mellituseng
dc.subject.keywordDipteraspa
dc.subject.keywordDisease modelseng
dc.subject.keywordLarvaspa
dc.subject.keywordRabbitsspa
dc.subject.keywordWound healingspa
dc.subject.keywordWound infectionspa
dc.subject.keywordBacterial infectionspa
dc.subject.keywordDiabetesspa
dc.subject.keywordLarval therapyspa
dc.subject.keywordLucilia sericataspa
dc.subject.keywordSarconesiopsis magellanicaspa
dc.subject.keywordWound healingspa
dc.titleEvaluating Sarconesiopsis magellanica blowfly-derived larval therapy and comparing it to Lucilia sericata-derived therapy in an animal modelspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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