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P. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.

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dc.creatorVanegas, Magnoliaspa
dc.creatorTovar, Dianaspa
dc.creatorLópez, Ramsesspa
dc.creatorPuentes, ALvarospa
dc.creatorGarcía, Javierspa
dc.creatorOcampo, Marisol
dc.date.accessioned2020-08-19T14:40:02Z
dc.date.available2020-08-19T14:40:02Z
dc.date.created2003-07spa
dc.description.abstractThis work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin were identified from the MSP-8 protein. Those amino acids directly involved in interaction with erythrocytes were also determined for each one of the HABPs. Some of them specifically recognized 28, 46, and 73 kDa erythrocyte membrane proteins. Some HABPs inhibited in vitro P. falciparum merozoite invasion of erythrocytes by up to 98%, suggesting the MSP-8 protein’s possible role in the invasion process.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/S0196-9781(03)00185-2
dc.identifier.issnISSN: 0196-9781
dc.identifier.issnEISSN: 1873-5169
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26683
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage1023
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1015
dc.relation.citationTitlePeptides
dc.relation.citationVolumeVol. 24
dc.relation.ispartofPeptides, ISSN: 0196-9781;EISSN: 1873-5169, Vol.24, No.7 (July 2003); pp. 1015-1023 spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0196978103001852?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourcePeptidesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordP. falciparumspa
dc.subject.keywordMSP-8spa
dc.subject.keywordHigh activity binding peptidesspa
dc.subject.keywordCritical residuesspa
dc.subject.keywordInvasion inhibitionspa
dc.titleP. falciparum: Merezoite Surface Protein-8 peptides bind specifically to human erythrocytes.spa
dc.title.TranslatedTitleP. falciparum: Los péptidos de la proteína de superficie 8 de merezoito se unen específicamente a los eritrocitos humanos.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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