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Spatio-temporal dynamics of Plasmodium falciparum transmission within a spatial unit on the Colombian Pacific Coast

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dc.creatorKnudson, Angélicaspa
dc.creatorGonzález-Casabianca, Felipespa
dc.creatorFeged Rivadeneira, Alejandrospa
dc.creatorPedreros, Maria Fernandaspa
dc.creatorAponte, Samandaspa
dc.creatorOlaya, Adrianaspa
dc.creatorCastillo, Carlos F.spa
dc.creatorMancilla, Elviraspa
dc.creatorPiamba-Dorado, Andersonspa
dc.creatorSanchez-Pedraza, Ricardospa
dc.creatorSalazar-Terreros, Myriam Janethspa
dc.creatorLucchi, Naomispa
dc.creatorUdhayakumar, Venkatachalamspa
dc.creatorJacob, Chrisspa
dc.creatorPance, Alenaspa
dc.creatorCarrasquilla, Manuelaspa
dc.creatorApráez, Giovannispa
dc.creatorAngel, Jairo Andrésspa
dc.creatorRayner, Julian C.spa
dc.creatorCorredor, Vladimirspa
dc.date.accessioned2020-05-26T00:00:52Z
dc.date.available2020-05-26T00:00:52Z
dc.date.created2020spa
dc.description.abstractAs malaria control programmes concentrate their efforts towards malaria elimination a better understanding of malaria transmission patterns at fine spatial resolution units becomes necessary. Defining spatial units that consider transmission heterogeneity, human movement and migration will help to set up achievable malaria elimination milestones and guide the creation of efficient operational administrative control units. Using a combination of genetic and epidemiological data we defined a malaria transmission unit as the area contributing 95% of malaria cases diagnosed at the catchment facility located in the town of Guapi in the South Pacific Coast of Colombia. We provide data showing that P. falciparum malaria transmission is heterogeneous in time and space and analysed, using topological data analysis, the spatial connectivity, at the micro epidemiological level, between parasite populations circulating within the unit. To illustrate the necessity to evaluate the efficacy of malaria control measures within the transmission unit in order to increase the efficiency of the malaria control effort, we provide information on the size of the asymptomatic reservoir, the nature of parasite genotypes associated with drug resistance as well as the frequency of the Pfhrp2/3 deletion associated with false negatives when using Rapid Diagnostic Tests. © 2020, The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/s41598-020-60676-1
dc.identifier.issn20452322
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23281
dc.language.isoengspa
dc.publisherNature Researchspa
dc.publisher.departmentFacultad de estudios internacionales políticos y urbanos
dc.relation.citationIssueNo. 1
dc.relation.citationTitleScientific Reports
dc.relation.citationVolumeVol. 10
dc.relation.ispartofScientific Reports, ISSN:20452322, Vol.10, No.1 (2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85080980434&doi=10.1038%2fs41598-020-60676-1&partnerID=40&md5=f92fb9b4eb5f7ee7003d54a4f519c0bdspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordSpatio-temporalspa
dc.subject.keyworddynamicsspa
dc.subject.keywordPlasmodiumspa
dc.subject.keywordfalciparumspa
dc.subject.keywordtransmissionspa
dc.subject.keywordwithinspa
dc.subject.keywordspatialspa
dc.subject.keywordunitspa
dc.subject.keywordColombianspa
dc.subject.keywordPacificspa
dc.subject.keywordCoastspa
dc.titleSpatio-temporal dynamics of Plasmodium falciparum transmission within a spatial unit on the Colombian Pacific Coastspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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