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Gamma interferon levels and antibody production induced by two PvMSP-1 recombinant polypeptides are associated with protective immunity against P. vivax in Aotus monkeys

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dc.creatorBarrero, Carlos A.spa
dc.creatorDelgado, Gabrielspa
dc.creatorSierra, Adriana Y.spa
dc.creatorSilva, Yolandaspa
dc.creatorParra-Lopez, Carlosspa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-08-19T14:43:44Z
dc.date.available2020-08-19T14:43:44Z
dc.date.created2005-07-01spa
dc.description.abstractEffector mechanisms responsible for providing protective immunity against Plasmodium vivax (Pv) infection were examined in Aotus monkeys vaccinated with two Pv Merozoite Surface Protein-1 (PvMSP-1) recombinant polypeptides that had previously been shown to protect vaccines against parasite challenge. Vaccine efficacy was reproducible in this trial, showing that one out of the five monkeys immunised with the recombinant protein mixture was partially protected while three others controlled parasitaemia. Antibodies reactive to the parasite's native proteins, the recombinant polypeptides and peptides spanning both recombinant fragments were detected in most vaccinees. Despite substantial Peripheral Blood Mononuclear Cell (PBMC) antigen-specific cellular proliferation not being detected, high rPvMSP-120 specific gamma interferon (IFN-?) production was found in the three animals that controlled parasitaemia. Altogether the results suggest that antibody titres and antigen-specific IFN-? production mediate protective immunity against P. vivax.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2005.02.012
dc.identifier.issnISSN: 0264-410X
dc.identifier.issnEISSN: 1873-2518
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27762
dc.language.isoengspa
dc.publisherThe Japanese Society for Vaccinologyspa
dc.publisherElsevierspa
dc.relation.citationEndPage4053
dc.relation.citationIssueNo. 31
dc.relation.citationStartPage4048
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 23
dc.relation.ispartofVaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.23, No.31 (2005); pp. 4048-4053 spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0264410X05002732spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceVaccinespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordMSP-1 33 kDa fragmentspa
dc.subject.keywordImmunisationspa
dc.subject.keywordImmune responsespa
dc.titleGamma interferon levels and antibody production induced by two PvMSP-1 recombinant polypeptides are associated with protective immunity against P. vivax in Aotus monkeysspa
dc.title.TranslatedTitleLos niveles de interferón gamma y la producción de anticuerpos inducida por dos polipéptidos recombinantes de PvMSP-1 están asociados con una inmunidad protectora contra P. vivax en monos Aotus.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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