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Variation in the serum IgA concentration and the production of IgA in vitro in rheumatoid arthritis treated by sulfasalazine

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dc.creatorJorgensen, C.spa
dc.creatorBologna, C.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorReme, T.spa
dc.creatorSany, J.spa
dc.date.accessioned2020-08-06T16:20:26Z
dc.date.available2020-08-06T16:20:26Z
dc.date.created1993-08-01spa
dc.description.abstractSulfasalazine is an efficient treatment for rheumatoid arthritis (RA), but its mode of action is not known. In RA, a correlation has been demonstrated between disease activity and the secretion of immunoglobulin A (IgA) by peripheral blood lymphocytes (PBL) in culture. Furthermore, the IgA-producing cells of the peripheral blood have been shown to originate from the mucous-associate lymphoid tissue (MALT). We studied the variations in the total IgA concentration in the serum of RA patients, and the secretion of IgA by PBL after 7 days culture in vitro, before and after treatment with sulfasalazine. A significant decrease in the serum IgA concentraton was obtained, but there was no modification of the spontaneous increase in the in vitro IgA synthesis by circulating monoclear cells. Our results suggested that the decrease in serum IgA concentration after treatment with sulfasalazine was not linked to a decrease in the IgA secretion by PBL. This does not favour a direct effect of sulfasalazine on the mucous-associated lymphoid tissue.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/BF00290298
dc.identifier.issnISSN: 0172-8172
dc.identifier.issnEISSN: 1437-160X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26008
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage116
dc.relation.citationStartPage113
dc.relation.citationTitleRheumatology International
dc.relation.citationVolumeVol. 13
dc.relation.ispartofRheumatology International, ISSN: 0172-8172;EISSN: 1437-160X, Vol.13 (August, 1993); pp.113-116spa
dc.relation.urihttps://link.springer.com/article/10.1007/BF00290298spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceRheumatology Internationalspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordMucous-associated lymphoid tissuespa
dc.subject.keywordImmunoglobulin Aspa
dc.subject.keywordSulfasalazinespa
dc.titleVariation in the serum IgA concentration and the production of IgA in vitro in rheumatoid arthritis treated by sulfasalazinespa
dc.title.TranslatedTitleVariación en la concentración sérica de IgA y la producción de IgA in vitro en artritis reumatoide tratada con sulfasalazinaeng
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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