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Laminin-1 (LM-111) in preeclampsia and systemic lupus erythematosus

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dc.creatorPáez, Maria-Carolinaspa
dc.creatorMatsuura, Eijispa
dc.creatorDíaz, Luis A.spa
dc.creatorShoenfeld, Yehudaspa
dc.creatorSerrano, Norma C.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:01:54Z
dc.date.available2020-05-26T00:01:54Z
dc.date.created2013spa
dc.description.abstractBackground: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of antibodies. SLE has been associated with placental pathology, a finding that is also the determinant in preeclampsia (PE). Genetic evidence and serologic reports suggest laminin-1 (LM-111) as an immunogenic molecule and its polymorphic gene as a candidate gene for both disorders. Objective: To evaluate the association between LAMA1 (rs543355) and LAMC1 (rs20563) polymorphisms and the presence of SLE and PE as well as to determine serum levels of anti-LM-111 autoantibodies in the PE group. Methods: Group A: 169 women with PE and 172 healthy pregnant women. Group B: 204 women with SLE and 204 healthy women. Anti-LM-111 for group A was measured by ELISA and the genotyping was done by using a PCR system. Results: Group A: Levels of anti-LM-111 was similar in women with PE and the control group (p = 0.3). The allelic frequencies and genotypes did not show statistically significant differences for LAMA1 and LAMC1 polymorphisms. Group B: Significant differences between SLE patients and controls for rs543355 polymorphism were not observed. Nevertheless, LAMC1 rs20563 A-allele provided protection against the development of SLE (OR 0.73, 95%CI 0.55-0.96). Conclusions: Serum levels of anti-LM-111 at the third trimester of gestation do not seem to have any direct relationship with the presence of PE, and the SNPs evaluated are not associated with the risk of developing this disorder. LAMC1 polymorphism could be a protective factor for SLE. © Informa UK, Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3109/08916934.2012.730586
dc.identifier.issn8916934
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23422
dc.language.isoengspa
dc.relation.citationEndPage20
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage14
dc.relation.citationTitleAutoimmunity
dc.relation.citationVolumeVol. 46
dc.relation.ispartofAutoimmunity, ISSN:8916934, Vol.46, No.1 (2013); pp. 14-20spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84872173547&doi=10.3109%2f08916934.2012.730586&partnerID=40&md5=ab2d616a84c45fd77749de0a8749810bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordsystemiceng
dc.subject.keywordLaminin 1spa
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordProtein antibodyspa
dc.subject.keywordAdultspa
dc.subject.keywordAntibody blood levelspa
dc.subject.keywordArticlespa
dc.subject.keywordCase control studyspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman tissuespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPreeclampsiaspa
dc.subject.keywordPregnant womanspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordThird trimester pregnancyspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordDnaspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordLamininspa
dc.subject.keywordLogistic modelsspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordMultivariate analysisspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordPre-eclampsiaspa
dc.subject.keywordPregnancyspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAnti-laminin-1spa
dc.subject.keywordLaminin alpha 1 (lama1)spa
dc.subject.keywordLaminin gamma 1 (lamc1)spa
dc.subject.keywordPreeclampsiaspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titleLaminin-1 (LM-111) in preeclampsia and systemic lupus erythematosusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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