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Primary biliary cirrhosis and the nuclear pore complex

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dc.creatorDuarte-Rey, Carolina
dc.creatorBogdanos, Dimitriosspa
dc.creatorYang, Chen-Yenspa
dc.creatorRoberts, Kristaspa
dc.creatorLeung, Patrick S.C.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorWorman, Howard J.spa
dc.creatorGershwin, M. Ericspa
dc.date.accessioned2020-05-25T23:59:52Z
dc.date.available2020-05-25T23:59:52Z
dc.date.created2012spa
dc.description.abstractExperimental models of autoimmune diseases have led to the conclusion that an immune response to nuclear antigens is a sentinel marker for loss of tolerance and potential tissue damage. Various proteins are targets of antinuclear antibodies in a variety of autoimmune diseases, ranging from systemic rheumatologic disorders to diseases affecting specific organs such as the liver. Autoantibodies against specific nuclear constituents have also been used as probes to understand the structure and the function of the targeted components and their relevance to disease pathogenesis. Approximately a quarter of patients with primary biliary cirrhosis (PBC) have antibodies targeting proteins of the nuclear pore complex (NPC), a multi-protein structure that mediates molecular transport across the nuclear envelope. Autoantibodies against the integral membrane glycoprotein gp210 and nucleoporin p62 appear to be highly specific for PBC, an autoimmune disease characterized by progressive destruction of intrahepatic biliary epithelial cells. This review discusses the diagnostic and clinical relevance of anti-NPC antibodies in PBC and the possibility that this autoimmune response may arise as a result of molecular mimicry. © 2012 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2012.03.005
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23122
dc.language.isoengspa
dc.relation.citationEndPage902
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage898
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 11
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.11, No.12 (2012); pp. 898-902spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84866561155&doi=10.1016%2fj.autrev.2012.03.005&partnerID=40&md5=6c3cc9006ec4e4781d832664af5b62fdspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntibodyspa
dc.subject.keywordbiliaryeng
dc.subject.keywordAntibody gp210spa
dc.subject.keywordAntibody nup62spa
dc.subject.keywordGlycoproteinspa
dc.subject.keywordGlycoprotein gp 210spa
dc.subject.keywordNucleoproteinspa
dc.subject.keywordNucleoprotein nup62spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAntibody productionspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCell nucleus membranespa
dc.subject.keywordHumanspa
dc.subject.keywordLiver transplantationspa
dc.subject.keywordMolecular diagnosisspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNuclear pore complexspa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordReviewspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordCross reactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordLiver cirrhosiseng
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordNuclear porespa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAutoantigenspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordNuclear envelopespa
dc.subject.keywordNuclear pore complexspa
dc.subject.keywordNucleoporinspa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.titlePrimary biliary cirrhosis and the nuclear pore complexspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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