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ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry

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dc.creatorKim-Howard, Xanaspa
dc.creatorMaiti, Amit Kspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorBruner, Gail Rspa
dc.creatorBrown, Elizabethspa
dc.creatorMerrill, Joan Tspa
dc.creatorEdberg, Jeffrey Cspa
dc.creatorPetri, Michelle Aspa
dc.creatorReveille, John Dspa
dc.creatorRamsey-Goldman, Rosalindspa
dc.creatorAlarcon, Graciela Sspa
dc.creatorVyse, Timothy Jspa
dc.creatorGilkeson, Garyspa
dc.creatorKimberly, Robert Pspa
dc.creatorJames, Judith Aspa
dc.creatorGuthridge, Joel Mspa
dc.creatorHarley, John Bspa
dc.creatorNath, Swapan Kspa
dc.date.accessioned2020-05-25T23:56:18Z
dc.date.available2020-05-25T23:56:18Z
dc.date.created2010spa
dc.description.abstractPurpose: It was hypothesised that the coding variant (R77H), rs1143679, within ITGAM could predict specific clinical manifestations associated with systemic lupus erythematosus (SLE). Method: To assess genetic association, 2366 patients with SLE and 2931 unaffected controls with European ancestry were analysed. The patients with SLE were coded by the presence or absence of individual American College of Rheumatology criteria. Logistic regression and Pearson ?2 tests were used to assess statistical significance. Results: For overall case-control analysis, a highly significant association was detected (p=2.22x10-21, OR 1.73). Using case-only analysis, a significant association was detected with renal criteria (p=0.0003), discoid rash (p=0.02) and immunological criteria (p=0.04). When patients with SLE were compared with healthy controls, the association became stronger for renal (p=4.69x10-22, OR 2.15), discoid (p=1.77x10-14, OR 2.03) and immunological (p=3.49x10-22, OR 1.86) criteria. Risk allele frequency increased from 10.6% (controls) to 17.0% (SLE), 20.4% (renal), 18.1% (immunological) and 19.5% (discoid). Conclusion: These results show a strong association between the risk allele (A) at rs1143679 and renal disease, discoid rash and immunological manifestations of SLE.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1136/ard.2009.120543
dc.identifier.issn00034967
dc.identifier.issn14682060
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22389
dc.language.isoengspa
dc.relation.citationEndPage1332
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1329
dc.relation.citationTitleAnnals of the Rheumatic Diseases
dc.relation.citationVolumeVol. 69
dc.relation.ispartofAnnals of the Rheumatic Diseases, ISSN:00034967, 14682060, Vol.69, No.7 (2010); pp. 1329-1332spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77954995416&doi=10.1136%2fard.2009.120543&partnerID=40&md5=76504477f2936ece85a79156c8ad8cdespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCD11b antigenspa
dc.subject.keywordITGAM antigenspa
dc.subject.keywordSystemiceng
dc.subject.keywordhumaneng
dc.subject.keywordDiscoideng
dc.subject.keywordCD11beng
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordCD11b antigenspa
dc.subject.keywordITGAM proteineng
dc.subject.keywordArthritisspa
dc.subject.keywordArticlespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDiscoid rashspa
dc.subject.keywordDisease associationspa
dc.subject.keywordEuropespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHematologic diseasespa
dc.subject.keywordHumanspa
dc.subject.keywordHypothesisspa
dc.subject.keywordImmunopathologyspa
dc.subject.keywordInflammationspa
dc.subject.keywordKidney diseasespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMouth ulcerspa
dc.subject.keywordNephritisspa
dc.subject.keywordNeurologic diseasespa
dc.subject.keywordPhotosensitivityspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRashspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordBloodspa
dc.subject.keywordDiscoid lupus erythematosusspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenotypespa
dc.subject.keywordImmunologyspa
dc.subject.keywordLupus erythematosus nephritisspa
dc.subject.keywordMalespa
dc.subject.keywordAntigenseng
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordFemalespa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordLupus Erythematosuseng
dc.subject.keywordLupus Erythematosuseng
dc.subject.keywordLupus Nephritisspa
dc.subject.keywordMalespa
dc.titleITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestryspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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