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Gluten sensitivity in multiple sclerosis: Experimental myth or clinical truth

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dc.creatorShor, Dana Ben?Amispa
dc.creatorBarzilai, Orispa
dc.creatorRam, Mayaspa
dc.creatorIzhaky, Davidspa
dc.creatorPorat?Katz, Bat Shevaspa
dc.creatorChapman, Joabspa
dc.creatorBlank, Mirispa
dc.creatorAnaya, Juan-Manuel
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-25T23:56:04Z
dc.date.available2020-05-25T23:56:04Z
dc.date.created2009spa
dc.description.abstractPatients with neurological disease of unknown etiology sometimes present with antigliadin and antitissue transglutaminase antibodies. The association between these antibodies and multiple sclerosis has been previously suggested. The purpose of this study was to determine the prevalence of these antibodies in multiple sclerosis patients. We determined the level of serum immunoglobulin A and immunoglobulin G antigliadin and antitissue transglutaminase antibodies in 98 patients with multiple sclerosis. We found a highly significant increase in titers of immunoglobulin G antibodies against gliadin and tissue transglutaminase in the multiple sclerosis patients. Seven patients had a positive IgG AGA, whereas only 2 controls presented positive titers (P = 0.03). Four patients had positive IgG anti-tTG while all the controls tested negative (P = 0.02). However, immunoglobulin A antibodies against gliadin and tissue transglutaminase were not statistically higher in the multiple sclerosis group in comparison to the control group. Our findings support the associations between antibodies against gliadin and tissue transglutaminase to multiple sclerosis. The specific role of these antibodies in the pathogenesis of multiple sclerosis remains uncertain and requires additional research. A gluten free diet should be considered in specific cases of patients who present with gluten antibodies. © 2009 New York Academy of Sciences.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1749-6632.2009.04620.x
dc.identifier.issn778923
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22311
dc.language.isoengspa
dc.publisherBlackwell Publishing Inc.spa
dc.relation.citationEndPage349
dc.relation.citationStartPage343
dc.relation.citationTitleAnnals of the New York Academy of Sciences
dc.relation.citationVolumeVol. 1173
dc.relation.ispartofAnnals of the New York Academy of Sciences, ISSN:778923, Vol.1173,(2009); pp. 343-349spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-69949176817&doi=10.1111%2fj.1749-6632.2009.04620.x&partnerID=40&md5=7b545cf2500c54b914bb09045650d80bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGliadin antibodyspa
dc.subject.keywordGlutenspa
dc.subject.keywordImmunoglobulin a antibodyspa
dc.subject.keywordImmunoglobulin g antibodyspa
dc.subject.keywordProtein glutamine gamma glutamyltransferase antibodyspa
dc.subject.keywordAdultspa
dc.subject.keywordAntibody detectionspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordConference paperspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordGluten free dietspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunopathogenesisspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordPrevalencespa
dc.subject.keywordSensitivity analysisspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGluten sensitivityspa
dc.subject.keywordImmunoglobulinsspa
dc.subject.keywordMultiple sclerosisspa
dc.titleGluten sensitivity in multiple sclerosis: Experimental myth or clinical truthspa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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