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Patients with Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity

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dc.creatorWolska, Ninaspa
dc.creatorRybakowska, Paulinaspa
dc.creatorRasmussen, Astridspa
dc.creatorBrown, Michaelspa
dc.creatorMontgomery, Courtneyspa
dc.creatorKlopocki, Arkadiuszspa
dc.creatorGrundahl, Kielyspa
dc.creatorScofield, Robert Hspa
dc.creatorRadfar, Lidaspa
dc.creatorStone, Donald Uspa
dc.creatorAnaya, Juan-Manuel
dc.creatorIce, John Aspa
dc.creatorLessard, Christopher Jspa
dc.creatorLewis, David Mspa
dc.creatorRhodus, Nelson Lspa
dc.creatorGopalakrishnan, Rajaramspa
dc.creatorHuang, Andrew J Wspa
dc.creatorHughes, Pamela Jspa
dc.creatorRohrer, Michael Dspa
dc.creatorWeisman, Michael Hspa
dc.creatorVenuturupalli, Swamyspa
dc.creatorGuthridge, Joel Mspa
dc.creatorJames, Judith Aspa
dc.creatorSivils, Kathy Lspa
dc.creatorBagavant, Harinispa
dc.creatorDeshmukh, Umesh Sspa
dc.date.accessioned2020-05-25T23:59:15Z
dc.date.available2020-05-25T23:59:15Z
dc.date.created2016spa
dc.description.abstractObjective Autoantibodies reactive with Ro52 (tripartite motif-containing protein 21 [TRIM21]) are detected in 70% of patients with primary Sjögren's syndrome (SS). TRIM21 belongs to a 34-member C-IV family of TRIM proteins. Although autoantibodies against other TRIM proteins within the C-IV family have been detected in the sera of patients with primary SS, their clinical relevance remains unclear. This study was undertaken to investigate the frequency of anti-TRIM38 in patients with primary SS and evaluate its association with various clinical measures of the disease. Methods Serum samples from patients with primary SS (n = 235) and controls (n = 50) were analyzed for reactivity with in vitro-transcribed and -translated 35S-methionine-labeled TRIM38 protein. The associations of anti-TRIM38 with various laboratory and clinical measures of primary SS were evaluated. Reactivity of anti-TRIM38 with different structural domains of TRIM38 was analyzed. Affinity-purified anti-TRIM38 antibodies were used to immunoprecipitate TRIM21. Results TRIM38-reactive autoantibodies were detected in the sera of 24 of the 235 patients with primary SS and 2 of the 50 controls. Anti-TRIM38 positivity was significantly associated with the presence of anti-Ro60, anti-Ro52, anti-La, rheumatoid factor, and hypergammaglobulinemia. Clinically, anti-TRIM38 was associated with significantly higher ocular surface staining scores, lower Schirmer's test scores, and minor labial salivary gland biopsy focus scores of ?3.0. Anti-TRIM38 antibodies mainly recognized the cortactin-binding protein 2 (CortBP-2; amino acids 128-238) and the B30.2/SPRY (amino acids 268-465) domains on TRIM38. Affinity-purified antibodies to TRIM38-CortBP-2 and TRIM38-B30.2/SPRY domains reacted with TRIM21. Conclusion Our data demonstrate that anti-TRIM38 specificity arising in a subset of patients with primary SS is associated with increased severity of the disease. © 2016, American College of Rheumatology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/art.39497
dc.identifier.issn23265205
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23011
dc.language.isoengspa
dc.publisherJohn Wiley and Sons Inc.spa
dc.relation.citationEndPage729
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage724
dc.relation.citationTitleArthritis and Rheumatology
dc.relation.citationVolumeVol. 68
dc.relation.ispartofArthritis and Rheumatology, ISSN:23265205, Vol.68, No.3 (2016); pp. 724-729spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84963864722&doi=10.1002%2fart.39497&partnerID=40&md5=81348a185384fb26a4f0bc03e5812ffbspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordhumaneng
dc.subject.keywordCortactin binding protein 2spa
dc.subject.keywordLa antibodyspa
dc.subject.keywordMembrane proteinspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordRo52 antibodyspa
dc.subject.keywordRo60 antibodyspa
dc.subject.keywordTripartite motif containing protein 21spa
dc.subject.keywordTripartite motif containing protein 38spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordCarrier proteinspa
dc.subject.keywordMethioninespa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordRibonucleoproteinspa
dc.subject.keywordSs-a antigenspa
dc.subject.keywordSulfurspa
dc.subject.keywordTrim38 proteineng
dc.subject.keywordAdultspa
dc.subject.keywordAntibody blood levelspa
dc.subject.keywordAntibody detectionspa
dc.subject.keywordAntibody specificityspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease severityspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordHypergammaglobulinemiaspa
dc.subject.keywordImmunoprecipitationspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein domainspa
dc.subject.keywordProtein familyspa
dc.subject.keywordSalivary gland biopsyspa
dc.subject.keywordSchirmer testspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordBloodspa
dc.subject.keywordImmunologyspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordCarrier proteinsspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordHypergammaglobulinemiaspa
dc.subject.keywordImmunoprecipitationspa
dc.subject.keywordMalespa
dc.subject.keywordMethioninespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordRibonucleoproteinsspa
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordSjogren's syndromespa
dc.subject.keywordSulfur radioisotopesspa
dc.titlePatients with Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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